Cubs vs. Marlins prediction: Why Cubs are favored to win Saturday's MLB matchup [9/5/2026]
Dimers' simulation model projects a 57.2% win probability for the Cubs at loanDepot park.

The Miami Marlins will take on the Chicago Cubs in MLB action at loanDepot park on Saturday, beginning at 4:10 PM ET.
The Marlins will send Ryan Gusto (1-3, 3.86 ERA) to the mound, pitting him against Javier Assad (6-1, 3.46 ERA) for the Cubs.
Dimers' advanced MLB model projects the Cubs as the most likely winner in this Cubs vs. Marlins prediction.
This article offers an expanded analysis of Saturday's matchup, including best bets and picks.
Cubs vs. Marlins prediction and odds
Our leading predictive model gives the Cubs a 57.2% chance of defeating the Marlins.
According to our model, the Marlins (+1.5) have a 55.5% chance of covering the run line, while the 8.5-run over/under has a 50.3% chance of staying under.
Latest betting odds
We have researched the best MLB odds in America for this game, which are listed here:
- Run Line: Cubs -1.5 (+138) / Marlins +1.5 (-144)
- Moneyline: Cubs -127, Marlins +122
- Total: Over/Under 8.5 (+104/-108)
All odds are correct at the time of publication and are subject to change.
Model picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:
- Run line: Cubs -1.5 @ 42¢ via Novig
- Moneyline: Cubs @ 56¢ via Novig
- Total: Over 8.5 @ 49¢ via Polymarket
According to our MLB best bets, the top play to make on this game is Cubs -1.5 at the spread.
These picks are based on our probabilities matched against the implied probabilities from the current available odds.
Game info & first pitch details
Saturday's MLB matchup between the Marlins and Cubs at loanDepot park is scheduled to begin at 4:10 PM ET.
- Who: Chicago Cubs vs. Miami Marlins
- Date: Saturday, September 5, 2026
- Time: 4:10 PM ET/1:10PM PT
- Venue: loanDepot park
Conclusion
We predict the Cubs, with a 57.2% win probability, will likely beat the Marlins in Saturday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.




