Cubs vs. Pirates prediction: Why Pittsburgh is favored to win Saturday's MLB matchup [7/25/2026]
Get Chicago Cubs vs Pittsburgh Pirates predictions for MLB Saturday.
MLB action continues on Saturday at 6:40 PM ET as the Chicago Cubs lock horns with the Pittsburgh Pirates at PNC Park.
The Pirates will send Paul Skenes (9-8, 3.43 ERA) to the mound, while the Cubs have opted for Shota Imanaga (6-8, 3.91 ERA).
Based on updated simulation results, Dimers' advanced MLB model predicts the Pirates as the most likely winner of the Cubs vs. Pirates game.
This article offers further insights into Saturday's matchup, including best bets and picks.
Cubs vs. Pirates prediction: Who will win and cover?
Our leading predictive model currently gives the Pirates a 55.9% chance of defeating the Cubs.
According to our model, the Cubs (+1.5) have a 61.3% chance of covering the run line, while the over/under total of 7.5 runs has a 53.9% chance of going over,.
Cubs vs. Pirates odds [7/25/2026]
We have sourced the best MLB odds in America for this game, which are listed here:
| Bet Type | Cubs | Pirates |
|---|---|---|
| Run Line | +1.5 (-170) | -1.5 (+168) |
| Moneyline | +125 | -127 |
| Total | o7.5 (-108) | u7.5 (+104) |
All odds are correct at the time of publication and are subject to change.
Cubs vs. Pirates picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Pirates -1.5 | +168 |
| Moneyline | Pirates | -127 |
| Total | Over 7.5 | -108 |
According to our MLB best bets, the top play to make on this game is Over 7.5 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Cubs vs. Pirates game-day updates and essential details
Saturday's MLB action between the Pirates and Cubs at PNC Park is scheduled to commence at 6:40 PM ET.
- Who: Chicago Cubs vs. Pittsburgh Pirates
- Date: Saturday, July 25, 2026
- Time: 6:40 PM ET/3:40PM PT
- Venue: PNC Park
Conclusion
We predict the Pirates, with a 55.9% win probability, will likely beat the Cubs in Saturday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
