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Read Article Cubs vs. Cardinals prediction: Cubs favored to win Friday's MLB matchup [5/29/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get Chicago Cubs vs St. Louis Cardinals predictions for MLB Friday.
MLB action continues on Friday at 7:15 PM ET as the Chicago Cubs square off with the St. Louis Cardinals at Busch Stadium.
The Cardinals will start Andre Pallante (5-4, 3.76 ERA), while the Cubs are going with Shota Imanaga (4-5, 4.04 ERA).
Based on updated simulations, Dimers' advanced MLB model predicts the Cubs as the most likely winner of the Cubs vs. Cardinals game.
This article offers further insights into Friday's matchup, including best bets and picks.
Cubs vs. Cardinals prediction: Who will win and cover?
Using innovative machine learning and statistical analysis, we have simulated the outcome of Friday's MLB matchup between the Cubs and Cardinals, forming part of our MLB predictions coverage.
Our leading predictive model currently gives the Cubs a 55% chance of defeating the Cardinals.
According to our model, the Cardinals (+1.5) have a 59% chance of covering the run line, while the 7.5-run over/under has a 54% chance of going over.
Cubs vs. Cardinals odds [5/29/2026]
We have sourced the best MLB odds in America for this game, which are listed here:
| Bet Type | Cubs | Cardinals |
|---|---|---|
| Run Line | -1.5 (+128) | +1.5 (-151) |
| Moneyline | -132 | +114 |
| Total | o7.5 (-112) | u7.5 (+100) |
All odds are correct at the time of publication and are subject to change.
Cubs vs. Cardinals picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Cardinals +1.5 | -151 |
| Moneyline | Cubs | -132 |
| Total | Over 7.5 | -112 |
According to our MLB best bets, the top play to make on this game is Over 7.5 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Cubs vs. Cardinals game-day updates and essential details
Friday's MLB matchup between the Cardinals and Cubs at Busch Stadium is scheduled to begin at 7:15 PM ET.
- Who: Chicago Cubs vs. St. Louis Cardinals
- Date: Friday, May 29, 2026
- Time: 7:15 PM ET/4:15PM PT
- Venue: Busch Stadium
Conclusion
We predict the Cubs, with a 55% win probability, will likely beat the Cardinals in Friday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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