White Sox vs. Cubs prediction: Why Cubs are favored to win Tuesday's MLB matchup [8/18/2026]

MLB action continues on Tuesday at 8:05 PM ET as the Chicago White Sox square off with the Chicago Cubs at Wrigley Field.

Kevin Gausman (6-11, 4.53 ERA) will be the starting pitcher for the Cubs, up against Bryan Hudson (3-4, 3.14 ERA) for the White Sox.

Dimers' proven MLB model projects the Cubs as the most likely winner in this White Sox vs. Cubs prediction.

This article offers a closer look at Tuesday's matchup, including best bets and picks.

White Sox vs. Cubs prediction: Who will win and cover?

Using innovative machine learning and data, we have simulated the outcome of Tuesday's MLB game between the White Sox and Cubs, forming part of our MLB predictions coverage.

Our leading predictive model gives the Cubs a 62.3% chance of beating the White Sox.

According to our model, the White Sox (+1.5) have a 54.5% chance of covering the run line, while the 9.5-run over/under has a 52.5% chance of staying under,.

White Sox vs. Cubs odds [8/18/2026]

We have sourced the best MLB odds in America for this game, which are listed here:

• Run Line: White Sox +1.5 (-127) / Cubs -1.5 (+122)
• Moneyline: White Sox +163, Cubs -163

All odds are correct at the time of publication and are subject to change.

White Sox vs. Cubs picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Run line: Cubs -1.5 @ +122 via DraftKings
• Moneyline: Cubs @ -163 via Polymarket
• Total: Over 9.5 @ +113 via Polymarket

According to our best MLB bets, the top play to make on this game is Over 9.5 total runs.

These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.

White Sox vs. Cubs game-day updates and essential details

Tuesday's MLB matchup between the Cubs and White Sox at Wrigley Field is scheduled to start at 8:05 PM ET.

• Who: Chicago White Sox vs. Chicago Cubs
• Date: Tuesday, August 18, 2026
• Time: 8:05 PM ET/5:05PM PT
• Venue: Wrigley Field

Conclusion

We predict the Cubs, with a 62.3% win probability, will likely beat the White Sox in Tuesday's MLB matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.