White Sox vs. Cubs prediction: Why Cubs are favored to win Tuesday's MLB matchup [8/18/2026]

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Written by Dave Garofolo

Get Chicago White Sox vs Chicago Cubs predictions for MLB Tuesday.

Chicago White Sox-Chicago Cubs Predictions and Game Preview.
Chicago White Sox vs. Chicago Cubs MLB prediction for Tuesday, August 18, 2026.

The Chicago Cubs and Chicago whitesox will meet in MLB action at Wrigley Field on Tuesday, starting at 8:05 PM ET.

Kevin Gausman (6-11, 4.53 ERA) will be the starting pitcher for the Cubs, while the White Sox are going with Bryan Hudson (3-4, 3.14 ERA).

Dimers' advanced MLB model projects the Cubs as the most likely winner in this White Sox vs. Cubs prediction.

This article offers an expanded analysis of Tuesday's matchup, including best bets and picks.

White Sox vs. Cubs prediction: Who will win and cover?

Using innovative machine learning and data, we have simulated the outcome of Tuesday's MLB matchup between the White Sox and Cubs, forming part of our MLB predictions coverage.

Our famous predictive model currently gives the Cubs a 61.8% chance of beating the White Sox.

According to our model, the White Sox (+1.5) have a 55.9% chance of covering the run line, while the 8.5-run over/under has a 55.5% chance of going over,.

 

White Sox vs. Cubs odds [8/18/2026]

We have researched the best MLB odds in America for this game, which are listed here:

  • Run Line: White Sox +1.5 (-138) / Cubs -1.5 (+135)
  • Moneyline: White Sox +150, Cubs -153

All odds are correct at the time of publication and are subject to change.

White Sox vs. Cubs picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

  • Run line: Cubs -1.5 @ +135 via DraftKings
  • Moneyline: Cubs @ -153 via Novig
  • Total: Over 8.5 @ -122 via Polymarket

According to our best MLB bets, the top play to make on this game is Cubs -1.5 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.

 

White Sox vs. Cubs game-day updates and essential details

Tuesday's MLB game between the Cubs and White Sox at Wrigley Field is scheduled to start at 8:05 PM ET.

Conclusion

We predict the Cubs, with a 61.8% win probability, will likely beat the White Sox in Tuesday's MLB matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

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Written by
Dave Garofolo
Content Producer

Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.

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