Aug 19, 2026
Braves vs. Twins prediction: Why Atlanta is favored to win Wednesday's MLB matchup [8/19/2026]
Read Article White Sox vs. Cubs prediction: Why Cubs are favored to win Wednesday's MLB matchup [8/19/2026]
Updated: | First published:
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Written by Dave Garofolo, Content Producer
Get Chicago White Sox vs Chicago Cubs predictions for MLB Wednesday.
The Chicago Cubs will take on the Chicago White Sox in MLB action at Wrigley Field on Wednesday, starting at 2:20 PM ET.
Clay Holmes (5-5, 2.56 ERA) will get the ball for the Cubs, while the White Sox have opted for Sean Newcomb (1-3, 2.52 ERA).
Dimers' advanced MLB model projects the Cubs as the most likely winner in this White Sox vs. Cubs prediction.
This article offers a closer look at Wednesday's matchup, including best bets and picks.
White Sox vs. Cubs prediction: Who will win and cover?
Using innovative machine learning and data analysis, we have simulated the result of Wednesday's MLB game between the White Sox and Cubs, forming part of our MLB predictions coverage.
Our famous predictive model currently gives the Cubs a 58.3% chance of beating the White Sox.
According to our model, the White Sox (+1.5) have a 59.9% chance of covering the run line, while the over/under total of 7.5 runs has a 56.5% chance of going over,.
White Sox vs. Cubs odds [8/19/2026]
We have sourced the best MLB odds in America for this game, which are listed here:
- Run Line: White Sox +1.5 (-160) / Cubs -1.5 (+155)
- Moneyline: White Sox +138, Cubs -140
All odds are correct at the time of publication and are subject to change.
White Sox vs. Cubs picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:
- Run line: Cubs -1.5 @ +155 via DraftKings
- Moneyline: Cubs @ -140 via Bet365
- Total: Over 7.5 @ -115 via Novig
According to our best MLB bets, the top play to make on this game is Over 7.5 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
White Sox vs. Cubs game-day updates and essential details
Wednesday's MLB matchup between the Cubs and White Sox at Wrigley Field is scheduled to begin at 2:20 PM ET.
- Who: Chicago White Sox vs. Chicago Cubs
- Date: Wednesday, August 19, 2026
- Time: 2:20 PM ET/11:20AM PT
- Venue: Wrigley Field
Conclusion
We predict the Cubs, with a 58.3% win probability, will likely beat the White Sox in Wednesday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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