Sep 14, 2026
Dodgers vs. Reds prediction: Why Dodgers are favored to win Monday's MLB matchup [9/14/2026]
Read Article White Sox vs. Guardians prediction: Why Cleveland is favored to win Monday's MLB matchup [9/14/2026]
Updated: | First published:
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Written by Jason Bevilacqua, Head of Content and Communities
Dimers' simulation model projects a 56.1% win probability for the Guardians at Progressive Field.
MLB action continues on Monday at 6:40 PM ET as the Chicago White Sox lock horns with the Cleveland Guardians at Progressive Field.
The Guardians will start Gavin Williams (13-7, 3.78 ERA), pitting him against Sean Newcomb (2-4, 2.78 ERA) for the White Sox.
Dimers' advanced MLB model projects the Guardians as the most likely winner in this White Sox vs. Guardians prediction.
This article offers a closer look at Monday's matchup, including best bets and picks.
For more, dive into Gavin Williams' pitching projections.
White Sox vs. Guardians prediction and odds
Using powerful machine learning and data, we have re-simulated the result of Monday's MLB matchup between the White Sox and Guardians, forming part of our MLB predictions coverage.
Our famous predictive model currently gives the Guardians a 56.1% chance of beating the White Sox. According to our model, the White Sox (+1.5) have a 62.4% chance of covering the run line, while the over/under total of 6.5 runs has a 60.1% chance of going over.
Latest betting odds
We have sourced the best MLB odds in America for this game, which are listed here:
- Run Line: White Sox +1.5 (-163) / Guardians -1.5 (+160)
- Moneyline: White Sox +138, Guardians -138
- Total: Over/Under 6.5 (-125/+117)
All odds are correct at the time of publication and are subject to change.
Model picks and best bet
After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:
- Run line: White Sox +1.5 @ 62¢ via Polymarket
- Moneyline: White Sox @ 42¢ via Polymarket
- Total: Over 6.5 @ -125 via BetMGM
According to our best MLB bets, the top play to make on this game is Over 6.5 total runs.
These picks are based on our probabilities matched against the implied probabilities from the current available odds.
Game info & first pitch details
Monday's MLB matchup between the Guardians and White Sox at Progressive Field is scheduled to commence at 6:40 PM ET.
- Who: Chicago White Sox vs. Cleveland Guardians
- Date: Monday, September 14, 2026
- Time: 6:40 PM ET/3:40PM PT
- Venue: Progressive Field
Conclusion
We predict the Guardians, with a 56.1% win probability, will likely beat the White Sox in Monday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
This article's predictions and probabilities are generated by Dimers' proprietary MLB prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.
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Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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