Reds vs. White Sox prediction: Why White Sox are favored to win Wednesday's MLB matchup [8/12/2026]
Get Cincinnati Reds vs Chicago White Sox predictions for MLB Wednesday.
The Chicago White Sox and Cincinnati Reds are scheduled to meet in MLB action at Rate Field on Wednesday, starting at 7:40 PM ET.
Luis Castillo (3-9, 5.30 ERA) will start for the White Sox, while the Reds will counter with Rhett Lowder (4-7, 5.26 ERA).
Dimers' advanced MLB model projects the White Sox as the most likely winner in this Reds vs. White Sox prediction.
This article offers a closer look at Wednesday's matchup, including best bets and picks.
Reds vs. White Sox prediction: Who will win and cover?
Our famous predictive model gives the White Sox a 57.0% chance of beating the Reds.
According to our model, the Reds (+1.5) have a 59.4% chance of covering the run line, while the 8.5-run over/under has a 55.7% chance of going over,.
Reds vs. White Sox odds [8/12/2026]
We have sourced the best MLB odds in America for this game, which are listed here:
- Run Line: Reds +1.5 (-150) / White Sox -1.5 (+150)
- Moneyline: Reds +138, White Sox -135
All odds are correct at the time of publication and are subject to change.
Reds vs. White Sox picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:
- Run line: White Sox -1.5 @ +150 via DraftKings
- Moneyline: Reds @ +138 via Polymarket
- Total: Over 8.5 @ -113 via Novig
According to our MLB best bets, the top play to make on this game is Over 8.5 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Reds vs. White Sox game-day updates and essential details
Wednesday's MLB action between the White Sox and Reds at Rate Field is scheduled to commence at 7:40 PM ET.
- Who: Cincinnati Reds vs. Chicago White Sox
- Date: Wednesday, August 12, 2026
- Time: 7:40 PM ET/4:40PM PT
- Venue: Rate Field
Conclusion
We predict the White Sox, with a 57.0% win probability, will likely beat the Reds in Wednesday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
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Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
