Jul 22, 2026
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Read Article Guardians vs. White Sox prediction: Why White Sox are favored to win Monday's MLB matchup [6/22/2026]
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Get Cleveland Guardians vs Chicago White Sox predictions for MLB Monday.
The Chicago White Sox will face the Cleveland Guardians, in what is expected to be a close MLB game, at Rate Field on Monday, beginning at 7:40 PM ET.
The White Sox will have Anthony Kay (6-2, 4.61 ERA) as their starting pitcher, pitting him against Gavin Williams (9-4, 3.83 ERA) for the Guardians.
Based on the latest simulation results, Dimers' proven MLB model gives the White Sox a slight edge with a 52.4% win probability over the Guardians.
This article offers an expanded analysis of Monday's Guardians vs. White Sox matchup, including best bets and picks.
Guardians vs. White Sox prediction: Who will win and cover?
Using trusted machine learning and statistical analysis, we have simulated the outcome of Monday's MLB game between the Guardians and White Sox, forming part of our MLB predictions coverage.
Our leading predictive model currently gives the White Sox a 52.4% chance of beating the Guardians.
According to our model, the White Sox (+1.5) have a 64.5% chance of covering the run line, while the 7.5-run over/under has a 51.3% chance of going over,.
Guardians vs. White Sox odds [6/22/2026]
We have sourced the best MLB odds in America for this game, which are listed here:
| Bet Type | Guardians | White Sox |
|---|---|---|
| Run Line | -1.5 (+155) | +1.5 (-185) |
| Moneyline | -110 | -106 |
| Total | o7.5 (-102) | u7.5 (-117) |
All odds are correct at the time of publication and are subject to change.
Guardians vs. White Sox picks and best bet
After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | White Sox +1.5 | -185 |
| Moneyline | White Sox | -106 |
| Total | Over 7.5 | -102 |
According to our MLB best bets, the top play to make on this game is White Sox to win.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Guardians vs. White Sox game-day updates and essential details
Monday's MLB matchup between the White Sox and Guardians at Rate Field is scheduled to start at 7:40 PM ET.
- Who: Cleveland Guardians vs. Chicago White Sox
- Date: Monday, June 22, 2026
- Time: 7:40 PM ET/4:40PM PT
- Venue: Rate Field
Conclusion
We predict the White Sox, with a 52.4% win probability, will likely beat the Guardians in Monday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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