MLB picks today: Saturday's MLB best bets include Reds vs. Diamondbacks play [8/22/2026]

Reds vs. Diamondbacks Over 8.5 runs (+117)

• Edge: 11.1%
• Probability: 57.2%
• Matchup: Reds vs. Diamondbacks (8:10PM ET)

Our model has identified value on Over 8.5 runs in Reds vs. Diamondbacks at +117 odds. A 57.2% probability produces an edge of 11.1%, making this the strongest play for today's MLB slate.

Angels vs. Rangers Over 8.5 runs (+113)

• Edge: 10.7%
• Probability: 57.7%
• Matchup: Angels vs. Rangers (7:05PM ET)

Angels vs. Rangers over 8.5 runs carries a 10.7% edge and a probability of 57.7% at +113 odds, according to our model.

Athletics vs. Astros Over 7.5 runs (-113)

• Edge: 8.4%
• Probability: 61.5%
• Matchup: Athletics vs. Astros (7:10PM ET)

Athletics vs. Astros Over 7.5 runs at -113 odds shows a 8.4% edge, supported by a 61.5% probability in simulations.

Nationals vs. Marlins over 7.5 runs (+108)

• Edge: 7.0%
• Probability: 55.1%
• Matchup: Nationals vs. Marlins (4:10PM ET)

A 7.0% edge and 55.1% probability make Nationals vs. Marlins over 7.5 runs a value play in the Nationals vs. Marlins matchup, per our model.

Giants vs. Red Sox Over 8.5 runs (+117)

• Edge: 6.1%
• Probability: 52.2%
• Matchup: Giants vs. Red Sox (7:15PM ET)

Giants vs. Red Sox Over 8.5 runs at +117 odds presents a 6.1% edge, with simulations resulting in a probability of 52.2%.

Rays vs. Orioles Over 7.5 runs (-109)

• Edge: 5.9%
• Probability: 58.1%
• Matchup: Rays vs. Orioles (7:05PM ET)

Our model finds value on Over 7.5 runs in Rays vs. Orioles at -109 odds, supported by an edge of 5.9%.

Tigers vs. Royals Over 8.5 runs (-104)

• Edge: 5.5%
• Probability: 56.4%
• Matchup: Tigers vs. Royals (7:15PM ET)

Our model has uncovered value on Tigers vs. Royals Over 8.5 runs at -104 odds. A 56.4% probability produces a 5.5% edge, making this a strong play for today's MLB action.

Giants ML (+194)

• Edge: 5.2%
• Probability: 39.2%
• Matchup: Giants vs. Red Sox (7:15PM ET)

A 5.2% edge on a 39.2% probability makes Giants to win at +194 odds a solid value play in today's Giants vs. Red Sox matchup.

Twins vs. PadresOver 8.5 runs (+111)

• Edge: 4.0%
• Probability: 51.4%
• Matchup: Twins vs. Padres (8:40PM ET)

Our model projects value on Over 8.5 runs at +111 odds. A 51.4% probability produces a 4.0% edge, making the Over the favorable side in today's matchup.

Giants +1.5 (-113)

• Edge: 3.9%
• Probability: 56.9%
• Matchup: Giants vs. Red Sox (7:15PM ET)

Rounding out our top 10 bets, Giants +1.5 at -113 odds shows a 56.9% probability and a 3.9% edge.

MLB best bets summary: Saturday, 8/22/2026

As of 2:09PM ET, here are our top MLB bets by edge recommended by our model:

List of upcoming MLB games to bet on [8/22/2026]

• Braves vs. Brewers (2:10PM ET, Saturday)
• Nationals vs. Marlins (4:10PM ET, Saturday)
• Cardinals vs. Phillies (6:05PM ET, Saturday)
• Rays vs. Orioles (7:05PM ET, Saturday)
• Angels vs. Rangers (7:05PM ET, Saturday)
• Athletics vs. Astros (7:10PM ET, Saturday)
• Mets vs. White Sox (7:10PM ET, Saturday)
• Tigers vs. Royals (7:15PM ET, Saturday)
• Cubs vs. Mariners (7:15PM ET, Saturday)
• Giants vs. Red Sox (7:15PM ET, Saturday)
• Pirates vs. Dodgers (7:15PM ET, Saturday)
• Guardians vs. Rockies (8:10PM ET, Saturday)
• Reds vs. D-Backs (8:10PM ET, Saturday)
• Twins vs. Padres (8:40PM ET, Saturday)
• Cardinals vs. Phillies (1:35PM ET, Sunday)
• Nationals vs. Marlins (1:40PM ET, Sunday)

Conclusion

Our MLB best bets are locked and loaded for August 22, 2026, featuring plays such as over 8.5 runs in the Reds vs. Diamondbacks matchup and over 8.5 runs in the Angels vs. Rangers matchup. Powered by advanced simulations, these picks are here to boost your betting game.

Our predictions are drawn from current data to help you make informed decisions. For additional resources and advice, head to our Responsible Gambling hub.

All odds and probabilities in this article are correct and accurate at the time of publication.