MLB picks today: Friday's MLB best bets include Cardinals vs. Diamondbacks play [7/17/2026]

Today’s MLB picks for July 17, 2026 are here, with Cardinals vs. Diamondbacks and Giants vs. Mariners among the top plays identified by our model across Friday’s MLB schedule.

Dimers’ predictive analytics engine runs 24/7, going over the latest baseball odds to uncover real betting edges. The result? Data-backed picks that help Dimers Pro members make smarter decisions.

List of MLB best bets tonight [7/17, updated 9:12PM ET]

Below, you’ll find today’s best baseball bets, ranked by edge for Friday, July 17, 2026.

Cardinals vs. Diamondbacks Over 9.5 runs (+122)

• Edge: 6.2%
• Probability: 51.2%
• Matchup: Cardinals vs. Diamondbacks (9:40PM ET)

Our model has identified value on Over 9.5 runs in Cardinals vs. Diamondbacks at +122 odds. A 51.2% probability produces an edge of 6.2%, making this the strongest play for today's MLB slate.

Giants vs. Mariners Over 7.5 runs (+117)

• Edge: 6.2%
• Probability: 52.3%
• Matchup: Giants vs. Mariners (10:10PM ET)

Giants vs. Mariners over 7.5 runs carries a 6.2% edge and a probability of 52.3% at +117 odds, according to our model.

Tigers vs. Angels Over 8.5 runs (+108)

• Edge: 4.4%
• Probability: 52.5%
• Matchup: Tigers vs. Angels (9:38PM ET)

Tigers vs. Angels Over 8.5 runs at +108 odds shows a 4.4% edge, supported by a 52.5% probability in simulations.

Athletics ML (+120)

• Edge: 4.3%
• Probability: 49.7%
• Matchup: Nationals vs. Athletics (9:40PM ET)

A 4.3% edge and 49.7% probability makes Athletics at the moneyline a value play in the Nationals vs. Athletics matchup, per our model.

Athletics +1.5 (-135)

• Edge: 3.4%
• Probability: 60.8%
• Matchup: Nationals vs. Athletics (9:40PM ET)

Athletics +1.5 at -135 odds presents a 3.4% edge, with simulations resulting in a probability of 60.8%.

Giants ML (+170)

• Edge: 2.7%
• Probability: 39.8%
• Matchup: Giants vs. Mariners (10:10PM ET)

Our model finds value on Giants to win at +170 odds, supported by an edge of 2.7%.

Diamondbacks ML (-106)

• Edge: 2.2%
• Probability: 53.7%
• Matchup: Cardinals vs. Diamondbacks (9:40PM ET)

Our model has uncovered value on Cardinals-Diamondbacks to finish as a tie after 90 minutes at -106 odds. A 53.7% probability produces a 2.2% edge, making this a strong play for today's MLB action.

Nationals vs. Athletics Over 10.5 runs (+113)

• Edge: 2.0%
• Probability: 48.9%
• Matchup: Nationals vs. Athletics (9:40PM ET)

A 2.0% edge on a 48.9% probability makes Over 10.5 runs at +113 odds a solid value play in today's Nationals vs. Athletics matchup.

MLB best bets summary: Friday, 7/17/2026

As of 9:12PM ET, here are our top MLB bets by edge recommended by our model:

List of upcoming MLB games to bet on [7/17/2026]

• Tigers vs. Angels (9:38PM ET, Friday)
• Nationals vs. Athletics (9:40PM ET, Friday)
• Cardinals vs. D-Backs (9:40PM ET, Friday)
• Giants vs. Mariners (10:10PM ET, Friday)
• Twins vs. Cubs (2:20PM ET, Saturday)
• White Sox vs. Blue Jays (3:07PM ET, Saturday)
• Mets vs. Phillies (4:05PM ET, Saturday)
• Marlins vs. Brewers (4:10PM ET, Saturday)
• Rays vs. Red Sox (4:10PM ET, Saturday)
• Orioles vs. Astros (4:10PM ET, Saturday)
• Cardinals vs. D-Backs (4:10PM ET, Saturday)
• Pirates vs. Guardians (4:10PM ET, Saturday)
• Rangers vs. Braves (4:10PM ET, Saturday)
• Dodgers vs. Yankees (8:08PM ET, Saturday)
• Giants vs. Mariners (8:08PM ET, Saturday)

Prediction market code for today's sports

To make the most of Friday's MLB best bets, as well as the Open Championship action, check out the new ProphetX sign-up offer that grants you a $20 trading bonus. Don't miss out!

Conclusion

Our MLB best bets are locked and loaded for July 17, 2026, featuring plays such as over 9.5 runs in the Cardinals vs. Diamondbacks matchup and over 7.5 runs in the Giants vs. Mariners matchup. Powered by advanced simulations, these picks are here to boost your betting game.

Our predictions are drawn from current data to help you make informed decisions. For additional resources and advice, head to our Responsible Gambling hub.

All odds and probabilities in this article are correct and accurate at the time of publication.