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Read Article MLB picks today: Monday's MLB best bets include Cubs vs. Mets play [6/22/2026]
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Get MLB picks today and best bets for Monday, June 22, 2026.
Today’s MLB picks for June 22, 2026 are here, with Cubs vs. Mets and Guardians vs. White Sox among the top plays identified by our model across Monday’s MLB slate.
Dimers’ predictive analytics engine runs 24/7, going over the latest baseball odds to discover legitimate betting edges. The result? Data-backed picks that help Dimers Pro members make smarter decisions.
List of MLB best bets tonight [6/22, updated 9:36PM ET]
Below, you’ll find today’s top 10 baseball bets, ranked by edge for Monday, June 22, 2026.
Cubs vs. Mets Over 5.5 runs (+100)
- Edge: 8.6%
- Probability: 58.6%
- Matchup: Cubs vs. Mets (7:10PM ET, Tuesday)
Our model has identified value on Over 5.5 runs in Cubs vs. Mets at +100 odds. A 58.6% probability produces an edge of 8.6%, making this the strongest play for today's MLB slate.
Guardians vs. White Sox Over 7.5 runs (+117)
- Edge: 5.9%
- Probability: 51.9%
- Matchup: Guardians vs. White Sox (7:40PM ET, Tuesday)
Guardians vs. White Sox over 7.5 runs carries a 5.9% edge and a probability of 51.9% at +117 odds, according to our model.
Dodgers vs. Twins Over 8.5 runs (+106)
- Edge: 5.8%
- Probability: 54.3%
- Matchup: Dodgers vs. Twins (7:40PM ET, Tuesday)
Dodgers vs. Twins Over 8.5 runs at +106 odds shows a 5.8% edge, supported by a 54.3% probability in simulations.
Braves vs. Padres over 7.5 runs (+111)
- Edge: 5.5%
- Probability: 53%
- Matchup: Braves vs. Padres (10:10PM ET)
A 5.5% edge and 53% probability make Braves vs. Padres over 7.5 runs a value play in the Braves vs. Padres matchup, per our model.
Red Sox vs. Rockies Over 10.5 runs (-102)
- Edge: 4.9%
- Probability: 55.4%
- Matchup: Red Sox vs. Rockies (8:40PM ET, Tuesday)
Red Sox vs. Rockies Over 10.5 runs at -102 odds presents a 4.9% edge, with simulations resulting in a probability of 55.4%.
Mets -1.5 (+182)
- Edge: 4.0%
- Probability: 39.5%
- Matchup: Cubs vs. Mets (7:10PM ET, Tuesday)
Our model finds value on Mets -1.5 at +182 odds, supported by an edge of 4.0%.
Yankees vs. Tigers Over 7.5 runs (-102)
- Edge: 3.7%
- Probability: 54.2%
- Matchup: Yankees vs. Tigers (6:40PM ET, Tuesday)
Our model has uncovered value on Yankees vs. Tigers Over 7.5 runs at -102 odds. A 54.2% probability produces a 3.7% edge, making this a strong play for today's MLB action.
Mariners vs. Pirates Over 8.5 runs (+115)
- Edge: 3.6%
- Probability: 50.1%
- Matchup: Mariners vs. Pirates (6:40PM ET, Tuesday)
A 3.6% edge on a 50.1% probability makes Over 8.5 runs at +115 odds a solid value play in today's Mariners vs. Pirates matchup.
Reds ML (+115)
- Edge: 3.4%
- Probability: 49.9%
- Matchup: Brewers vs. Reds (7:10PM ET, Tuesday)
Our model projects value on Reds to win at +115 odds. A 49.9% probability produces a 3.4% edge, making Reds the favorable ML play in today's matchup.
Diamondbacks vs. Cardinals Over 8.5 runs (-102)
- Edge: 3.0%
- Probability: 53.5%
- Matchup: Diamondbacks vs. Cardinals (7:45PM ET, Tuesday)
Rounding out our top 10 bets, Diamondbacks vs. Cardinals Over 8.5 runs at -102 odds shows a 53.5% probability and a 3.0% edge.
MLB best bets summary: Monday, 6/22/2026
As of 9:36PM ET, here are our top MLB bets by edge recommended by our model:
| Matchup | Bet | Odds | Edge | Probability |
|---|---|---|---|---|
| Cubs vs. Mets | Over 5.5 runs | +100 @ Polymarket | 8.6% | 58.6% |
| Guardians vs. White Sox | Over 7.5 runs | +117 @ Kalshi | 5.9% | 51.9% |
| Dodgers vs. Twins | Over 8.5 Runs | +106 @ Kalshi | 5.8% | 54.3% |
| Braves vs. Padres | over 7.5 runs | +111 @ Kalshi | 5.5% | 53% |
| Red Sox vs. Rockies | Over 10.5 Runs | -102 @ Kalshi | 4.9% | 55.4% |
| Cubs vs. Mets | Mets -1.5 | +182 @ Kalshi | 4.0% | 39.5% |
| Yankees vs. Tigers | Over 7.5 Runs | -102 @ Kalshi | 3.7% | 54.2% |
| Mariners vs. Pirates | Over 8.5 Runs | +115 @ Polymarket | 3.6% | 50.1% |
| Brewers vs. Reds | Reds ML | +115 @ Kalshi | 3.4% | 49.9% |
| Diamondbacks vs. Cardinals | Over 8.5 Runs | -102 @ Kalshi | 3.0% | 53.5% |
List of upcoming MLB games to bet on [6/22/2026]
- Orioles vs. Angels (9:38PM ET, Monday)
- Braves vs. Padres (10:10PM ET, Monday)
- Astros vs. Blue Jays (4:07PM ET, Tuesday)
- Mariners vs. Pirates (6:40PM ET, Tuesday)
- Yankees vs. Tigers (6:40PM ET, Tuesday)
- Royals vs. Rays (6:40PM ET, Tuesday)
- Phillies vs. Nationals (6:45PM ET, Tuesday)
- Cubs vs. Mets (7:10PM ET, Tuesday)
- Brewers vs. Reds (7:10PM ET, Tuesday)
- Dodgers vs. Twins (7:40PM ET, Tuesday)
- Guardians vs. White Sox (7:40PM ET, Tuesday)
- D-Backs vs. Cardinals (7:45PM ET, Tuesday)
- Red Sox vs. Rockies (8:40PM ET, Tuesday)
Conclusion
Our MLB best bets are locked and loaded for June 22, 2026, featuring plays such as Over 5.5 runs in the Cubs vs. Mets matchup and Over 7.5 runs in the Guardians vs. White Sox matchup. Powered by advanced simulations, these picks are here to boost your betting game.
Our predictions are sourced from current data to help you make informed decisions. For additional resources and advice, head to our Responsible Gambling hub.
All odds and probabilities in this article are correct and accurate at the time of publication.
Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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