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Read Article MLB picks today: Tuesday's MLB best bets include Mariners vs. Athletics play [5/26/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get MLB picks today and best bets for Tuesday, May 26, 2026.
Today’s MLB picks for May 26, 2026 are here, with Mariners vs. Athletics and Braves vs. Red Sox among the top plays identified by our model across Tuesday’s MLB slate.
Dimers’ predictive analytics engine runs 24/7, going over the latest baseball odds to uncover real betting edges. The result? Data-backed picks that help Dimers Pro members make smarter decisions.
List of MLB best bets tonight [5/26, updated 9:24PM ET]
Below, you’ll find today’s top 10 baseball bets, ranked by edge for Tuesday, May 26, 2026.
Mariners vs. Athletics over 6.5 runs (+100)
- Edge: 7.8%
- Probability: 57.8%
- Matchup: Mariners vs. Athletics (3:05PM ET, Wednesday)
Our model has identified value on over 6.5 runs in Mariners vs. Athletics at +100 odds. A 57.8% probability produces an edge of 7.8%, making this the strongest play for today's MLB slate.
Braves vs. Red Sox over 8.5 runs (+113)
- Edge: 7.1%
- Probability: 54.1%
- Matchup: Braves vs. Red Sox (6:45PM ET, Wednesday)
Braves vs. Red Sox over 8.5 runs carries a 7.1% edge and a probability of 54.1% at +113 odds, according to our model.
Astros vs. Rangers over 7.5 runs (-108)
- Edge: 5.3%
- Probability: 57.3%
- Matchup: Astros vs. Rangers (8:05PM ET, Wednesday)
Astros vs. Rangers over 7.5 runs at -108 odds shows a 5.3% edge, supported by a 57.3% probability in simulations.
Diamondbacks vs. Giants over 7.5 runs (-106)
- Edge: 5.0%
- Probability: 56.5%
- Matchup: Diamondbacks vs. Giants (3:45PM ET, Wednesday)
A 5.0% edge and 56.5% probability make Diamondbacks vs. Giants over 7.5 runs at a value play in the Diamondbacks vs. Giants matchup, per our model.
Nationals vs. Guardians over 7.5 runs (-111)
- Edge: 5.0%
- Probability: 57.5%
- Matchup: Nationals vs. Guardians (1:10PM ET, Wednesday)
Nationals vs. Guardians over 7.5 runs at -111 odds presents a 5.0% edge, with simulations resulting in a probability of 57.5%.
Angels vs. Tigers over 7.5 runs (-106)
- Edge: 4.9%
- Probability: 56.4%
- Matchup: Angels vs. Tigers (6:40PM ET, Wednesday)
Our model finds value on over 7.5 runs in Angels vs. Tigers at -106 odds, supported by an edge of 4.9%.
Twins vs. White Sox over 8.5 runs (+104)
- Edge: 4.4%
- Probability: 53.4%
- Matchup: Twins vs. White Sox (7:40PM ET, Wednesday)
Our model has uncovered value on Twins vs. White Sox over 8.5 runs at +104 odds. A 53.4% probability produces a 4.4% edge, making this a strong play for today's MLB action.
Phillies vs. Padres over 7.5 runs (+106)
- Edge: 4.2%
- Probability: 52.7%
- Matchup: Phillies vs. Padres (9:40PM ET, Tuesday)
A 4.2% edge on a 52.7% probability makes over 7.5 runs at +106 odds a solid value play in today's Phillies vs. Padres matchup.
Marlins vs. Blue Jays over 7.5 runs (-106)
- Edge: 4.2%
- Probability: 55.7%
- Matchup: Marlins vs. Blue Jays (1:07PM ET, Wednesday)
Our model projects value on over 7.5 runs at -106 odds. A 55.7% probability produces a 4.2% edge, making the over the favorable side in Saturday’s matchup.
Phillies vs. Padres over 7.5 runs (+106)
- Edge: 3.8%
- Probability: 52.3%
- Matchup: Phillies vs. Padres (4:10PM ET, Wednesday)
Rounding out our top 10 bets, Phillies vs. Padres over 7.5 runs at +106 odds shows a 52.3% probability and a 3.8% edge.
MLB best bets summary: Tuesday, 5/26/2026
As of 9:24PM ET, here are our top MLB bets by edge recommended by our model:
| Matchup | Bet | Odds | Edge | Probability |
|---|---|---|---|---|
| Mariners vs. Athletics | Over 6.5 Runs | +100 @ Polymarket | 7.8% | 57.8% |
| Braves vs. Red Sox | Over 8.5 Runs | +113 @ Polymarket | 7.1% | 54.1% |
| Astros vs. Rangers | Over 7.5 Runs | -108 @ Kalshi | 5.3% | 57.3% |
| Diamondbacks vs. Giants | Over 7.5 Runs | -106 @ Polymarket | 5.0% | 56.5% |
| Nationals vs. Guardians | Over 7.5 Runs | -111 @ Polymarket | 5.0% | 57.5% |
| Angels vs. Tigers | Over 7.5 Runs | -106 @ Polymarket | 4.9% | 56.4% |
| Twins vs. White Sox | Over 8.5 Runs | +104 @ Polymarket | 4.4% | 53.4% |
| Phillies vs. Padres | Over 7.5 Runs | +106 @ Polymarket | 4.2% | 52.7% |
| Marlins vs. Blue Jays | Over 7.5 Runs | -106 @ Polymarket | 4.2% | 55.7% |
| Phillies vs. Padres | Over 7.5 Runs | +106 @ Polymarket | 3.8% | 52.3% |
List of upcoming MLB games to bet on [5/26/2026]
- Mariners vs. Athletics (9:40PM ET, Tuesday)
- Phillies vs. Padres (9:40PM ET, Tuesday)
- D-Backs vs. Giants (9:45PM ET, Tuesday)
- Rockies vs. Dodgers (10:10PM ET, Tuesday)
- Marlins vs. Blue Jays (1:07PM ET, Wednesday)
- Nationals vs. Guardians (1:10PM ET, Wednesday)
- Cardinals vs. Brewers (1:40PM ET, Wednesday)
- Mariners vs. Athletics (3:05PM ET, Wednesday)
- D-Backs vs. Giants (3:45PM ET, Wednesday)
- Phillies vs. Padres (4:10PM ET, Wednesday)
- Rays vs. Orioles (6:35PM ET, Wednesday)
- Angels vs. Tigers (6:40PM ET, Wednesday)
- Cubs vs. Pirates (6:40PM ET, Wednesday)
- Braves vs. Red Sox (6:45PM ET, Wednesday)
- Yankees vs. Royals (7:40PM ET, Wednesday)
- Twins vs. White Sox (7:40PM ET, Wednesday)
- Astros vs. Rangers (8:05PM ET, Wednesday)
Conclusion
Our MLB best bets are locked and loaded for May 26, 2026, featuring plays such as over 6.5 runs in the Mariners vs. Athletics matchup and over 8.5 runs in the Braves vs. Red Sox matchup. Powered by advanced simulations, these picks are here to boost your betting game.
Our predictions are drawn from current data to help you make informed decisions. For additional resources and advice, head to our Responsible Gambling hub.
All odds and probabilities in this article are correct and accurate at the time of publication.
Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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