MLB picks today: Tuesday's MLB best bets include two over/under plays [9/23/2025]

Padres +1.5 (-152)

• Probability: 62.8%
• Edge: 2.5%
• Matchup: Brewers vs. Padres (9:40PM ET, Tuesday)

Our model has pinpointed a high-probability MLB betting opportunity tonight, which comes in the Brewers vs. Padres matchup. We recommend a run line bet on Padres +1.5 at -152 odds, with our analysis showing a 62.8% chance of hitting and a compelling edge of 2.5%.

Rockies vs. Mariners over 8 runs (-110)

• Probability: 57.6%
• Edge: 5.2%
• Matchup: Rockies vs. Mariners (9:40PM ET, Tuesday)

Our model has found another strong MLB bet for Tuesday's baseball action, this time in the matchup between the Rockies and Mariners. We suggest placing an over/under wager on over 8 runs at -110 odds, with a 57.6% probability delivering a 5.2% edge.

Brewers vs. Padres over 8 runs (-110)

• Probability: 57.2%
• Edge: 4.8%
• Matchup: Brewers vs. Padres (9:40PM ET, Tuesday)

Our model has found another strong MLB bet for Tuesday's baseball action, this time in the Brewers vs. Padres game. We recommend an over/under bet on over 8 runs at -110 odds. Our projections shows a 57.2% probability and 4.8% edge for this wager.

MLB best bets: Tuesday, 9/23/2025

As of 9:33PM ET, here are our top three MLB bets by probability recommended by our model:

The bets listed here are sorted by win probability—but the real path to profit lies in high-edge plays. Dimers Pro unlocks instant access to the most valuable bets across all sports, powered by our advanced predictive model.

Among today's MLB picks is a +170 run line bet with a 9.5% edge—the kind of high-upside play that makes a difference over time.

List of upcoming MLB games to bet on [9/23/2025]

• Royals vs. Angels (9:38PM ET, Tuesday)
• Dodgers vs. D-Backs (9:40PM ET, Tuesday)
• Brewers vs. Padres (9:40PM ET, Tuesday)
• Rockies vs. Mariners (9:40PM ET, Tuesday)
• Cardinals vs. Giants (9:45PM ET, Tuesday)
• Astros vs. Athletics (10:05PM ET, Tuesday)
• Nationals vs. Braves (12:15PM ET, Wednesday)
• Rays vs. Orioles (6:35PM ET, Wednesday)
• Pirates vs. Reds (6:40PM ET, Wednesday)
• Tigers vs. Guardians (6:40PM ET, Wednesday)
• Marlins vs. Phillies (6:45PM ET, Wednesday)
• Red Sox vs. Blue Jays (7:07PM ET, Wednesday)
• Mets vs. Cubs (8:05PM ET, Wednesday)

More about MLB

The bets on this page form part of our MLB player props and MLB best bets series.

For more MLB betting content, we have MLB trends for every game, as well as daily MLB betting news and the latest World Series odds and predictions.

Conclusion

Our MLB best bets are locked and loaded for September 23, 2025, featuring plays such as Padres +1.5 and over 8 runs in the Rockies vs. Mariners matchup. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate MLB insights quickly, with human oversight ensuring high editorial quality. Our predictions are sourced from current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.

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