Yankees vs. Tigers prediction: Detroit favored to win Monday's MLB matchup [6/22/2026]
Get New York Yankees vs Detroit Tigers predictions for MLB Monday.

MLB action continues on Monday at 6:10 PM ET as the New York Yankees square off with the Detroit Tigers at Comerica Park.
The Tigers will have Framber Valdez (3-5, 4.09 ERA) as their starting pitcher, while the Yankees have opted for Gerrit Cole (2-1, 2.57 ERA).
Based on the latest simulation results, Dimers' proven MLB model gives the Tigers a slight edge with a 50.5% win probability over the Yankees.
This article offers further insights into Monday's Yankees vs. Tigers matchup, including best bets and picks.
Yankees vs. Tigers prediction: Who will win and cover?
Our independent predictive model currently gives the Tigers a 50.5% chance of beating the Yankees.
According to our model, the Tigers (+1.5) have a 61.9% chance of covering the run line, while the over/under total of 8.5 runs has a 50.4% chance of staying under,.
Yankees vs. Tigers odds [6/22/2026]
We have sourced the best MLB odds in America for this game, which are listed here:
| Bet Type | Yankees | Tigers |
|---|---|---|
| Run Line | -1.5 (+132) | +1.5 (-154) |
| Moneyline | -125 | +108 |
| Total | o8.5 (-110) | u8.5 (-105) |
All odds are correct at the time of publication and are subject to change.
Yankees vs. Tigers picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Tigers +1.5 | -154 |
| Moneyline | Tigers | +108 |
| Total | Under 8.5 | -105 |
According to our MLB best bets, the top play to make on this game is Tigers to win.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Yankees vs. Tigers game-day updates and essential details
Monday's MLB game between the Tigers and Yankees at Comerica Park is scheduled to start at 6:10 PM ET.
- Who: New York Yankees vs. Detroit Tigers
- Date: Monday, June 22, 2026
- Time: 6:10 PM ET/3:10PM PT
- Venue: Comerica Park
Conclusion
We predict the Tigers, with a 50.5% win probability, will likely beat the Yankees in Monday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.



