Pirates vs. Dodgers prediction: Dodgers favored to win Friday's MLB matchup [8/21/2026]
Get Pittsburgh Pirates vs Los Angeles Dodgers predictions for MLB Friday.

The Los Angeles Dodgers will face the Pittsburgh Pirates in MLB action at UNIQLO Field at Dodger Stadium on Friday, beginning at 10:10 PM ET.
The Dodgers will start Yoshinobu Yamamoto (12-7, 2.60 ERA), while the Pirates are going with Bubba Chandler (6-8, 4.23 ERA).
Dimers' proven MLB model projects the Dodgers as the most likely winner in this Pirates vs. Dodgers prediction.
This article offers a closer look at Friday's matchup, including best bets and picks.
For more, dive into Yoshinobu Yamamoto's pitching projections.
Pirates vs. Dodgers prediction: Who will win and cover?
Our famous predictive model gives the Dodgers a 68.7% chance of defeating the Pirates.
According to our model, the Dodgers (-1.5) have a 51.9% chance of covering the run line, while the 7.5-run over/under has a 58.9% chance of going over.
Pirates vs. Dodgers odds [8/21/2026]
We have researched the best MLB odds in America for this game, which are listed here:
- Run Line: Pirates +1.5 (+106) / Dodgers -1.5 (-108)
- Moneyline: Pirates +220, Dodgers -223
All odds are correct at the time of publication and are subject to change.
Pirates vs. Dodgers picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:
- Run line: Dodgers -1.5 @ -108 via DraftKings
- Moneyline: Pirates @ +220 via DraftKings
- Total: Over 7.5 @ -117 via Polymarket
According to our MLB best bets, the top play to make on this game is Over 7.5 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Pirates vs. Dodgers game-day updates and essential details
Friday's MLB matchup between the Dodgers and Pirates at UNIQLO Field at Dodger Stadium is scheduled to commence at 10:10 PM ET.
- Who: Pittsburgh Pirates vs. Los Angeles Dodgers
- Date: Friday, August 21, 2026
- Time: 10:10 PM ET/7:10PM PT
- Venue: UNIQLO Field at Dodger Stadium
Conclusion
We predict the Dodgers, with a 68.7% win probability, will likely beat the Pirates in Friday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.



