Pirates vs. Yankees prediction: Yankees favored to win Wednesday's MLB matchup [7/22/2026]
Get Pittsburgh Pirates vs New York Yankees predictions for MLB Wednesday.
MLB action continues on Wednesday at 1:35 PM ET as the Pittsburgh Pirates lock horns with the New York Yankees at Yankee Stadium.
Gerrit Cole (3-5, 3.93 ERA) will start for the Yankees, up against Mitch Keller (6-7, 5.14 ERA) for the Pirates.
Based on the latest simulation results, Dimers' advanced MLB model projects the Yankees as the most likely winner of the Pirates vs. Yankees game.
This article offers further insights into Wednesday's matchup, including best bets and picks.
Pirates vs. Yankees prediction: Who will win and cover?
Our independent predictive model currently gives the Yankees a 61.6% chance of defeating the Pirates.
According to our model, the Pirates (+1.5) have a 54.7% chance of covering the run line, while the over/under total of 8.5 runs has a 54.7% chance of going over,.
Pirates vs. Yankees odds [7/22/2026]
We have sourced the best MLB odds in America for this game, which are listed here:
| Bet Type | Pirates | Yankees |
|---|---|---|
| Run Line | +1.5 (-134) | -1.5 (+123) |
| Moneyline | +150 | -144 |
| Total | o8.5 (-115) | u8.5 (+100) |
All odds are correct at the time of publication and are subject to change.
Pirates vs. Yankees picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Yankees -1.5 | +123 |
| Moneyline | Yankees | -144 |
| Total | Over 8.5 | -115 |
According to our MLB best bets, the top play to make on this game is Yankees to win.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Pirates vs. Yankees game-day updates and essential details
Wednesday's MLB action between the Yankees and Pirates at Yankee Stadium is scheduled to commence at 1:35 PM ET.
- Who: Pittsburgh Pirates vs. New York Yankees
- Date: Wednesday, July 22, 2026
- Time: 1:35 PM ET/10:35AM PT
- Venue: Yankee Stadium
Conclusion
We predict the Yankees, with a 61.6% win probability, will likely beat the Pirates in Wednesday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
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Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
