Cardinals vs. Cubs prediction: Why Cubs are favored to win Sunday's MLB matchup [8/16/2026]
Get St. Louis Cardinals vs Chicago Cubs predictions for MLB Sunday.
The Chicago Cubs will square off with the St. Louis Cardinals in MLB action at Wrigley Field on Sunday, commencing at 3:15 PM ET.
Edward Cabrera (5-4, 5.10 ERA) will get the ball for the Cubs, while the Cardinals will counter with Hunter Dobbins (2-3, 3.40 ERA).
Dimers' advanced MLB model projects the Cubs as the most likely winner in this Cardinals vs. Cubs prediction.
This article offers further insights into Sunday's matchup, including best bets and picks.
Cardinals vs. Cubs prediction: Who will win and cover?
Our leading predictive model currently gives the Cubs a 59.4% chance of defeating the Cardinals.
According to our model, the Cardinals (+1.5) have a 57.8% chance of covering the run line, while the 8.5-run over/under has a 54.4% chance of going over,.
Cardinals vs. Cubs odds [8/16/2026]
We have sourced the best MLB odds in America for this game, which are listed here:
- Run Line: Cardinals +1.5 (-144) / Cubs -1.5 (+141)
- Moneyline: Cardinals +145, Cubs -147
All odds are correct at the time of publication and are subject to change.
Cardinals vs. Cubs picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:
- Run line: Cubs -1.5 @ +141 via DraftKings
- Moneyline: Cubs @ -147 via Novig
- Total: Over 8.5 @ -115 via Novig
According to our MLB best bets, the top play to make on this game is Over 8.5 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Cardinals vs. Cubs game-day updates and essential details
Sunday's MLB game between the Cubs and Cardinals at Wrigley Field is scheduled to begin at 3:15 PM ET.
- Who: St. Louis Cardinals vs. Chicago Cubs
- Date: Sunday, August 16, 2026
- Time: 3:15 PM ET/12:15PM PT
- Venue: Wrigley Field
Conclusion
We predict the Cubs, with a 59.4% win probability, will likely beat the Cardinals in Sunday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
