Jul 22, 2026
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Read Article Cardinals vs. Cubs prediction: Why Cubs are favored to win Friday's MLB matchup [7/3/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get St. Louis Cardinals vs Chicago Cubs predictions for MLB Friday.
The Chicago Cubs and St. Louis Cardinals will meet in MLB action at Wrigley Field on Friday, starting at 4:05 PM ET.
David Peterson (4-6, 5.86 ERA) will start for the Cubs, up against Andre Pallante (9-5, 3.83 ERA) for the Cardinals.
Based on the latest simulation results, Dimers' proven MLB model predicts the Cubs as the most likely winner of the Cardinals vs. Cubs game.
This article offers a closer look at Friday's matchup, including best bets and picks.
Cardinals vs. Cubs prediction: Who will win and cover?
Using trusted machine learning and data analysis, we have simulated the result of Friday's MLB game between the Cardinals and Cubs, forming part of our MLB predictions coverage.
Our famous predictive model gives the Cubs a 55.9% chance of beating the Cardinals.
According to our model, the Cardinals (+1.5) have a 59.4% chance of covering the run line, while the 10.5-run over/under has a 52.2% chance of staying under,.
Cardinals vs. Cubs odds [7/3/2026]
We have researched the best MLB odds in America for this game, which are listed here:
| Bet Type | Cardinals | Cubs |
|---|---|---|
| Run Line | +1.5 (-174) | -1.5 (+150) |
| Moneyline | +114 | -126 |
| Total | o10.5 (-120) | u10.5 (+100) |
All odds are correct at the time of publication and are subject to change.
Cardinals vs. Cubs picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Cubs -1.5 | +150 |
| Moneyline | Cubs | -126 |
| Total | Under 10.5 | +100 |
According to our MLB best bets, the top play to make on this game is Under 10.5 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Cardinals vs. Cubs game-day updates and essential details
Friday's MLB matchup between the Cubs and Cardinals at Wrigley Field is scheduled to begin at 4:05 PM ET.
- Who: St. Louis Cardinals vs. Chicago Cubs
- Date: Friday, July 3, 2026
- Time: 4:05 PM ET/1:05PM PT
- Venue: Wrigley Field
Conclusion
We predict the Cubs, with a 55.9% win probability, will likely beat the Cardinals in Friday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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