Jul 22, 2026
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Read Article Cardinals vs. Cubs prediction: Why Cubs are favored to win Sunday's MLB matchup [7/5/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get St. Louis Cardinals vs Chicago Cubs predictions for MLB Sunday.
The Chicago Cubs and St. Louis Cardinals will lock horns in MLB action at Wrigley Field on Sunday, starting at 2:30 PM ET.
Javier Assad (6-1, 4.53 ERA) will get the ball for the Cubs, up against Matthew Liberatore (4-5, 5.34 ERA) for the Cardinals.
Based on the latest simulation results, Dimers' advanced MLB model predicts the Cubs as the most likely winner of the Cardinals vs. Cubs game.
This article offers an expanded analysis of Sunday's matchup, including best bets and picks.
Cardinals vs. Cubs prediction: Who will win and cover?
Using innovative machine learning and data analysis, we have simulated the result of Sunday's MLB game between the Cardinals and Cubs, forming part of our MLB predictions coverage.
Our famous predictive model currently gives the Cubs a 59.8% chance of beating the Cardinals.
According to our model, the Cardinals (+1.5) have a 57.4% chance of covering the run line, while the 8-run over/under has a 51.4% chance of going over,.
Cardinals vs. Cubs odds [7/5/2026]
We have researched the best MLB odds in America for this game, which are listed here:
| Bet Type | Cardinals | Cubs |
|---|---|---|
| Run Line | +1.5 (-188) | -1.5 (+155) |
| Moneyline | +120 | -142 |
| Total | o8 (-110) | u8 (-105) |
All odds are correct at the time of publication and are subject to change.
Cardinals vs. Cubs picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Cubs -1.5 | +155 |
| Moneyline | Cubs | -142 |
| Total | Over 8 | -110 |
According to our best MLB bets, the top play to make on this game is Cubs -1.5 at the spread.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Cardinals vs. Cubs game-day updates and essential details
Sunday's MLB action between the Cubs and Cardinals at Wrigley Field is scheduled to begin at 2:30 PM ET.
- Who: St. Louis Cardinals vs. Chicago Cubs
- Date: Sunday, July 5, 2026
- Time: 2:30 PM ET/11:30AM PT
- Venue: Wrigley Field
Conclusion
We predict the Cubs, with a 59.8% win probability, will likely beat the Cardinals in Sunday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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