Cardinals vs. Reds prediction: Why Cincinnati is favored to win Wednesday's MLB matchup [8/19/2026]

The Cincinnati Reds will square off with the St. Louis Cardinals in MLB action at Great American Ball Park on Wednesday, commencing at 6:40 PM ET.

Chase Burns (14-2, 2.47 ERA) will be on the bump for the Reds, pitting him against Matthew Liberatore (5-10, 5.07 ERA) for the Cardinals.

Dimers' advanced MLB model projects the Reds as the most likely winner in this Cardinals vs. Reds prediction.

This article offers further insights into Wednesday's matchup, including best bets and picks.

For more, dive into Chase Burns' pitching projections.

Cardinals vs. Reds prediction: Who will win and cover?

Using trusted machine learning and statistical analysis, we have simulated the outcome of Wednesday's MLB game between the Cardinals and Reds, forming part of our MLB predictions coverage.

Our leading predictive model gives the Reds a 58.1% chance of beating the Cardinals.

According to our model, the Cardinals (+1.5) have a 59.5% chance of covering the run line, while the over/under total of 8.5 runs has a 50.9% chance of going over,.

Cardinals vs. Reds odds [8/19/2026]

We have researched the best MLB odds in America for this game, which are listed here:

• Run Line: Cardinals +1.5 (-163) / Reds -1.5 (+160)
• Moneyline: Cardinals +128, Reds -127

All odds are correct at the time of publication and are subject to change.

Cardinals vs. Reds picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Run line: Reds -1.5 @ +160 via DraftKings
• Moneyline: Reds @ -127 via Novig
• Total: Over 8.5 @ +108 via Novig

According to our MLB best bets, the top play to make on this game is Over 8.5 total runs.

These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.

Cardinals vs. Reds game-day updates and essential details

Wednesday's MLB matchup between the Reds and Cardinals at Great American Ball Park is scheduled to begin at 6:40 PM ET.

• Who: St. Louis Cardinals vs. Cincinnati Reds
• Date: Wednesday, August 19, 2026
• Time: 6:40 PM ET/3:40PM PT
• Venue: Great American Ball Park

Conclusion

We predict the Reds, with a 58.1% win probability, will likely beat the Cardinals in Wednesday's MLB matchup.

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