Aug 20, 2026
Athletics vs. Royals prediction: Kansas City favored to win Thursday's MLB matchup [8/20/2026]
Read Article Cardinals vs. Reds prediction: Why Cincinnati is favored to win Thursday's MLB matchup [8/20/2026]
Updated: | First published:
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Written by Dave Garofolo, Content Producer
Get St. Louis Cardinals vs Cincinnati Reds predictions for MLB Thursday.
MLB action continues on Thursday at 12:40 PM ET as the St. Louis Cardinals take on the Cincinnati Reds at Great American Ball Park.
The Reds will send Brady Singer (5-11, 4.66 ERA) to the mound, up against Michael McGreevy (5-9, 3.48 ERA) for the Cardinals.
Dimers' advanced MLB model gives the Reds a slight edge with a 50.5% win probability over the Cardinals.
This article offers a complete Cardinals vs. Reds prediction, including best bets and picks.
Cardinals vs. Reds prediction: Who will win and cover?
Using trusted machine learning and data analysis, we have simulated the outcome of Thursday's MLB matchup between the Cardinals and Reds, forming part of our MLB predictions coverage.
Our independent predictive model gives the Reds a 50.5% chance of beating the Cardinals.
According to our model, the Reds (+1.5) have a 61.8% chance of covering the run line, while the 8.5-run over/under has a 56.5% chance of going over,.
Cardinals vs. Reds odds [8/20/2026]
We have researched the best MLB odds in America for this game, which are listed here:
- Run Line: Cardinals -1.5 (+147) / Reds +1.5 (-150)
- Moneyline: Cardinals -104, Reds +105
All odds are correct at the time of publication and are subject to change.
Cardinals vs. Reds picks and best bet
After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:
- Run line: Reds +1.5 @ -150 via DraftKings
- Moneyline: Reds @ +105 via Bet365
- Total: Over 8.5 @ -122 via Polymarket
According to our best MLB bets, the top play to make on this game is Reds +1.5 at the spread.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Cardinals vs. Reds game-day updates and essential details
Thursday's MLB game between the Reds and Cardinals at Great American Ball Park is scheduled to commence at 12:40 PM ET.
- Who: St. Louis Cardinals vs. Cincinnati Reds
- Date: Thursday, August 20, 2026
- Time: 12:40 PM ET/9:40AM PT
- Venue: Great American Ball Park
Conclusion
We predict the Reds, with a 50.5% win probability, will likely beat the Cardinals in Thursday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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