Cardinals vs. Angels prediction: Angels favored to win Wednesday's MLB matchup [7/22/2026]
Get St. Louis Cardinals vs Los Angeles Angels predictions for MLB Wednesday.
The Los Angeles Angels will square off with the St. Louis Cardinals in MLB action at Angel Stadium on Wednesday, beginning at 4:07 PM ET.
Reid Detmers (3-6, 4.16 ERA) will be on the bump for the Angels, up against Hunter Dobbins (1-1, 4.03 ERA) for the Cardinals.
Based on the latest simulations, Dimers' advanced MLB model predicts the Angels as the most likely winner of the Cardinals vs. Angels game.
This article offers an expanded analysis of Wednesday's matchup, including best bets and picks.
Cardinals vs. Angels prediction: Who will win and cover?
Our leading predictive model gives the Angels a 55.8% chance of beating the Cardinals.
According to our model, the Cardinals (+1.5) have a 62.6% chance of covering the run line, while the over/under total of 9.5 runs has a 54.6% chance of staying under,.
Cardinals vs. Angels odds [7/22/2026]
We have sourced the best MLB odds in America for this game, which are listed here:
| Bet Type | Cardinals | Angels |
|---|---|---|
| Run Line | +1.5 (-200) | -1.5 (+165) |
| Moneyline | +108 | -113 |
| Total | o9.5 (+117) | u9.5 (-117) |
All odds are correct at the time of publication and are subject to change.
Cardinals vs. Angels picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Angels -1.5 | +165 |
| Moneyline | Angels | -113 |
| Total | Under 9.5 | -117 |
According to our MLB best bets, the top play to make on this game is Under 9.5 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Cardinals vs. Angels game-day updates and essential details
Wednesday's MLB action between the Angels and Cardinals at Angel Stadium is scheduled to begin at 4:07 PM ET.
- Who: St. Louis Cardinals vs. Los Angeles Angels
- Date: Wednesday, July 22, 2026
- Time: 4:07 PM ET/1:07PM PT
- Venue: Angel Stadium
Conclusion
We predict the Angels, with a 55.8% win probability, will likely beat the Cardinals in Wednesday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
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Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
