Aug 22, 2026
Blue Jays vs. Yankees prediction: Yankees favored to win Saturday's MLB matchup [8/22/2026]
Read Article Cardinals vs. Phillies prediction: Why Philadelphia is favored to win Saturday's MLB matchup [8/22/2026]
Updated: | First published:
Add Dimers on Google 
Written by Dave Garofolo, Content Producer
Get St. Louis Cardinals vs Philadelphia Phillies predictions for MLB Saturday.
The Philadelphia Phillies will take on the St. Louis Cardinals in MLB action at Citizens Bank Park on Saturday, commencing at 6:05 PM ET.
The Phillies will send Andrew Painter (2-8, 6.43 ERA) to the mound, up against Quinn Mathews (0-1, 3.00 ERA) for the Cardinals.
Dimers' advanced MLB model projects the Phillies as the most likely winner in this Cardinals vs. Phillies prediction.
This article offers further insights into Saturday's matchup, including best bets and picks.
Cardinals vs. Phillies prediction: Who will win and cover?
Using trusted machine learning and data, we have simulated the outcome of Saturday's MLB game between the Cardinals and Phillies, forming part of our MLB predictions coverage.
Our leading predictive model currently gives the Phillies a 59.3% chance of beating the Cardinals.
According to our model, the Cardinals (+1.5) have a 58.8% chance of covering the run line, while the over/under total of 8.5 runs has a 57.1% chance of going over.
Cardinals vs. Phillies odds [8/22/2026]
We have researched the best MLB odds in America for this game, which are listed here:
- Run Line: Cardinals +1.5 (-144) / Phillies -1.5 (+175)
- Moneyline: Cardinals +156, Phillies -130
All odds are correct at the time of publication and are subject to change.
Cardinals vs. Phillies picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:
- Run line: Phillies -1.5 @ +175 via DraftKings
- Moneyline: Cardinals @ +156 via Novig
- Total: Over 8.5 @ -117 via Novig
According to our MLB best bets, the top play to make on this game is Phillies -1.5 at the spread.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Cardinals vs. Phillies game-day updates and essential details
Saturday's MLB game between the Phillies and Cardinals at Citizens Bank Park is scheduled to commence at 6:05 PM ET.
- Who: St. Louis Cardinals vs. Philadelphia Phillies
- Date: Saturday, August 22, 2026
- Time: 6:05 PM ET/3:05PM PT
- Venue: Citizens Bank Park
Conclusion
We predict the Phillies, with a 59.3% win probability, will likely beat the Cardinals in Saturday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
Continue reading with Dimers Pro
Join now to unlock this article and get full access to our predictions and betting tools. Cancel anytime.
EARLY BIRD PRICE
6 months of Dimers Pro
Full football season covered
NFL + College Football
One payment. Renews in 6 months.
Your Pro access is locked in for 6 months. Cancel or pause anytime.
Access to every sport, all season long.
Everything in Dimers Pro - not just football
Already a Pro member? Log in
New here? See everything Pro includes
Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
Advertiser disclosure
