Sep 22, 2026
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Read Article Cardinals vs. Pirates prediction: Why Pittsburgh is favored to win Tuesday's MLB matchup [9/22/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Dimers' simulation model projects a 60.4% win probability for the Pirates at PNC Park.
The Pittsburgh Pirates and St. Louis Cardinals are scheduled to meet in MLB action at PNC Park on Tuesday, starting at 6:40 PM ET.
The Pirates will send Jared Jones (4-6, 4.17 ERA) to the mound, while the Cardinals have opted for Andre Pallante (12-7, 3.70 ERA).
Dimers' proven MLB model projects the Pirates as the most likely winner in this Cardinals vs. Pirates prediction.
This article offers an expanded analysis of Tuesday's matchup, including best bets and picks.
Cardinals vs. Pirates prediction and odds
Using trusted machine learning and data, we have re-simulated the outcome of Tuesday's MLB matchup between the Cardinals and Pirates, forming part of our MLB predictions coverage.
Our independent predictive model currently gives the Pirates a 60.4% chance of defeating the Cardinals. According to our model, the Cardinals (+1.5) have a 59.2% chance of covering the run line, while the 7.5-run over/under has a 51.5% chance of staying under.
Latest betting odds
We have sourced the best MLB odds in America for this game, which are listed here:
- Run Line: Cardinals +1.5 (-150) / Pirates -1.5 (+150)
- Moneyline: Cardinals +160, Pirates -150
- Total: Over/Under 7.5 (+120/-122)
All odds are correct at the time of publication and are subject to change.
Model picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:
- Run line: Pirates -1.5 @ +150 via bet365
- Moneyline: Cardinals @ 38¢ via Novig
- Total: Over 7.5 @ 45¢ via Novig
According to our MLB best bets, the top play to make on this game is Over 7.5 total runs.
These picks are based on our probabilities matched against the implied probabilities from the current available odds.
Game info & first pitch details
Tuesday's MLB action between the Pirates and Cardinals at PNC Park is scheduled to start at 6:40 PM ET.
- Who: St. Louis Cardinals vs. Pittsburgh Pirates
- Date: Tuesday, September 22, 2026
- Time: 6:40 PM ET/3:40PM PT
- Venue: PNC Park
Conclusion
We predict the Pirates, with a 60.4% win probability, will likely beat the Cardinals in Tuesday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
This article's predictions and probabilities are generated by Dimers' proprietary MLB prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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