Blue Jays vs. Yankees prediction: Yankees favored to win Friday's MLB matchup [8/21/2026]

The New York Yankees will square off with the Toronto Blue Jays in MLB action at Yankee Stadium on Friday, commencing at 7:05 PM ET.

Cam Schlittler (10-6, 2.19 ERA) will be on the bump for the Yankees, pitting him against Mason Fluharty (5-1, 3.71 ERA) for the Blue Jays.

Dimers' proven MLB model projects the Yankees as the most likely winner in this Blue Jays vs. Yankees prediction.

This article offers a closer look at Friday's matchup, including best bets and picks.

For more, dive into Cam Schlittler's pitching projections.

Blue Jays vs. Yankees prediction: Who will win and cover?

Using powerful machine learning and data, we have simulated the outcome of Friday's MLB matchup between the Blue Jays and Yankees, forming part of our MLB predictions coverage.

Our leading predictive model currently gives the Yankees a 60.7% chance of defeating the Blue Jays.

According to our model, the Blue Jays (+1.5) have a 57.5% chance of covering the run line, while the 7-run over/under has a 59.2% chance of going over.

Blue Jays vs. Yankees odds [8/21/2026]

We have sourced the best MLB odds in America for this game, which are listed here:

• Run Line: Blue Jays +1.5 (-127) / Yankees -1.5 (+120)
• Moneyline: Blue Jays +180, Yankees -182

All odds are correct at the time of publication and are subject to change.

Blue Jays vs. Yankees picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Run line: Blue Jays +1.5 @ -127 via DraftKings
• Moneyline: Blue Jays @ +180 via DraftKings
• Total: Over 7 @ -105 via BetRivers

According to our MLB best bets, the top play to make on this game is Over 7 total runs.

These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.

Blue Jays vs. Yankees game-day updates and essential details

Friday's MLB action between the Yankees and Blue Jays at Yankee Stadium is scheduled to begin at 7:05 PM ET.

• Who: Toronto Blue Jays vs. New York Yankees
• Date: Friday, August 21, 2026
• Time: 7:05 PM ET/4:05PM PT
• Venue: Yankee Stadium

Conclusion

We predict the Yankees, with a 60.7% win probability, will likely beat the Blue Jays in Friday's MLB matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.