FC Cincinnati vs. D.C. United prediction, odds, MLS Cup Wildcard Round picks [10/21/2026]

Cincinnati will square off with D.C. United in the MLS Cup Wildcard Round at TQL Stadium on Wednesday, commencing at 7:00 PM ET.

Dimers' advanced MLS model projects Cincinnati as the most likely winner in this Cincinnati vs. D.C. United prediction.

This article offers further insights into Wednesday's match, including best bets and picks.

FC Cincinnati vs. D.C. United prediction and odds

Using trusted machine learning and data, we have re-simulated the result of Wednesday's MLS matchup between Cincinnati and D.C. United, forming part of our MLS predictions coverage.

Our leading predictive model currently suggests a 63.6% chance of Cincinnati winning, an 18.8% chance for D.C. United, and a 17.6% chance of a draw. Additionally, the 2.5-goal over/under has a 76.4% chance of going over., according to our model.

Latest betting odds

We have researched the best MLS odds in America for this game, which are listed here:

• Moneyline: D.C. United +410, Cincinnati -150
• Total Goals: Over/Under 2.5 (-317/+292)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet for MLS Cup Wildcard Round

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Moneyline: Cincinnati @ -150 via Fanatics
• Total Goals: Over 2.5 @ -317 via Polymarket

According to our MLS best bets, the top play to make on this game is Cincinnati to win.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Correct score projections

Here are the top three most likely final scores according to our model, with a 2-1 Cincinnati win being the most probable:

• Cincinnati 2-1 D.C. United (8.6% probability)
• Cincinnati 3-1 D.C. United (7.5%)
• Cincinnati 1-1 D.C. United (6.6%)

Game info & kickoff details

Wednesday's MLS game between Cincinnati and D.C. United in MLS at TQL Stadium is scheduled to commence at 7:00 PM ET.

• Who: FC Cincinnati vs. D.C. United
• Date: Wednesday, October 21, 2026
• Time: 7:00 PM ET/4:00 PM PT
• Venue: TQL Stadium

Conclusion

According to our computer model, Cincinnati has a 63.6% win probability on Wednesday, D.C. United has an 18.8% win probability, and there is a 17.6% chance that the game will end in a draw.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary MLS prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.