Jul 22, 2026
LA Galaxy vs. St Louis City prediction, odds, MLS picks [7/22/2026]
Read Article MLS betting tips: Wednesday's picks include Orlando vs. San Jose play [7/22/2026]
Updated: | First published:
Written by Nick Slade, Chief Content Officer
Get MLS betting tips and picks for Wednesday, July 22, 2026.
Today’s MLS betting tips for July 22, 2026 are here, with Orlando vs. San Jose and Dallas vs. Portland among the top plays identified by our model across Wednesday’s MLS action.
Dimers’ predictive analytics engine runs 24/7, scanning the latest soccer odds to unearth top betting edges. The result? Data-backed picks that help Dimers Pro members make smarter decisions.
List of MLS betting tips tonight [7/22, updated 9:41PM ET]
Below, you’ll find today’s best soccer bets, ranked by edge for Wednesday, July 22, 2026.
San Jose ML (-149)
- Edge: 5.5%
- Probability: 65.4%
- Matchup: Orlando vs. San Jose (10:30PM ET)
Our model has identified value on San Jose to defeat Orlando at -149 odds. A 65.4% probability produces an edge of 5.5%, making this the strongest play for today's MLS slate.
Portland ML (+135)
- Edge: 2.6%
- Probability: 45.1%
- Matchup: Dallas vs. Portland (10:30PM ET)
Portland ML carries a 2.6% edge and a probability of 45.1% at +135 odds, according to our model.
MLS best bets summary: Wednesday, 7/22/2026
As of 9:41PM ET, here are our top MLS bets by edge recommended by our model:
| Matchup | Bet | Odds | Edge | Probability |
|---|---|---|---|---|
| Orlando vs. San Jose | San Jose ML | -149 @ ESPN BET | 5.5% | 65.4% |
| Dallas vs. Portland | Portland ML | +135 @ ESPN BET | 2.6% | 45.1% |
List of upcoming MLS games to bet on [7/22/2026]
- Dallas vs. Portland (10:30PM ET, Wednesday)
- Salt Lake vs. LAFC (10:30PM ET, Wednesday)
- St Louis City vs. LA Galaxy (10:30PM ET, Wednesday)
- Orlando vs. San Jose (10:30PM ET, Wednesday)
Conclusion
Our MLS best bets are locked and loaded for July 22, 2026, featuring plays such as San Jose ML vs. Orlando and Portland ML. Powered by advanced simulations, these picks are here to boost your betting game.
Our predictions are based on current data to help you make informed decisions. For additional resources and advice, head to our Responsible Gambling hub.
All odds and probabilities in this article are correct and accurate at the time of publication.
Nick Slade, with nearly two decades of experience, is the Chief Content Officer at Cipher Sports Technology Group, overseeing content for Dimers. He specializes in soccer, NBA, and NHL betting, leveraging predictive analytics and machine learning to provide accurate betting insights.
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