Cavaliers vs. 76ers prediction, odds and best bet for Oct. 22, 2026

The Philadelphia 76ers are favored to beat the Cleveland Cavaliers on Thursday, according to Dimers' NBA pregame model.

Our Cavaliers vs. 76ers prediction gives Philadelphia a 63.5% chance of winning at Xfinity Mobile Arena, with the latest odds also suggesting value in betting on the 76ers to win.

Cavaliers vs. 76ers: Key predictions

• Predicted score: 76ers 119-115 Cavaliers
• 76ers win probability: 63.5%
• Cavaliers win probability: 36.5%
• Cavaliers +2.5 spread: 50.2% cover probability
• Under 236.5 points: 52.3% probability

Dimers' NBA pregame model uses machine learning to predict each team's score, accounting for player performance, expected minutes, matchups, availability, and home-court advantage. These scores inform our NBA predictions, including win, spread, and total probabilities, which we compare with available odds to identify betting value.

Cavaliers vs. 76ers odds

Here are the best available odds across the moneyline, spread, and total points markets monitored by Dimers.

• Cavaliers moneyline: 44¢ (Novig)
• 76ers moneyline: 56¢ (Polymarket)
• Cavaliers +2.5: 51¢ (Novig)
• 76ers -2.5: 50¢ (Novig)
• Over 236.5 points: 52¢ (Polymarket)
• Under 236.5 points: 49¢ (Polymarket)

Odds are subject to change and may vary by location.

Best value bet: 76ers moneyline (56¢)

With Philadelphia favored to beat Cleveland, Dimers' top value bet is the 76ers moneyline at 56¢, available at Polymarket.

Those odds imply the 76ers have a 55.9% chance of winning, while our model puts that probability at 63.5%.

That's a 7.6% edge in the 76ers' favor, the largest across the moneyline, spread, and total points markets based on Dimers' probabilities and the best available odds.

Cavaliers vs. 76ers player projections

Unlike our team-focused NBA pregame model, Dimers' NBA player props model projects points, rebounds, assists, and more, accounting for recent form, expected minutes, injuries, lineup changes, and defensive matchups.

Donovan Mitchell leads our scoring projections for this matchup, with the Cavaliers star also expected to add 4.9 assists and 4.4 rebounds. The 76ers have three players among the top five projected scorers, compared to the Cavaliers' two.

Top 5 projected scorers

• Donovan Mitchell (Cavaliers): 26.0 points
• Joel Embiid (76ers): 23.7
• Jaylen Brown (76ers): 23.5
• Tyrese Maxey (76ers): 22.3
• James Harden (Cavaliers): 19.7

Projections across all major stat categories are available for every player expected to take the court on our NBA player projections page.

These are statistical projections, not betting recommendations. Compare them with available odds to assess potential value.

Unlock all Cavaliers vs. 76ers predictions with Dimers Pro

Get the complete picture for Thursday's matchup with Dimers Pro, including:

• Best bets for the moneyline, spread, and total points markets.
• Points, rebounds, and assists projections for players on both teams.
• High-value player props across points, rebounds, assists, three-pointers, steals, and blocks markets.

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Cavaliers vs. 76ers game details

• Matchup: Cleveland Cavaliers vs. Philadelphia 76ers
• Date: Thursday, October 22, 2026
• Time: 7:00 PM ET/4:00 PM PT
• Venue: Xfinity Mobile Arena

About this prediction

This preview uses predictions from Dimers' proprietary NBA models, presented through a human-written template. Matchup-specific information is populated automatically.

Predictions are estimates, not guarantees, and may change as new information becomes available. Learn more about how Dimers predictions work.

Dimers encourages responsible gambling.