San Luis vs. Guadalajara prediction, odds, Liga MX picks [9/5/2026]

Atletico San Luis will square off with Guadalajara in Liga MX action at Estadio Libertad Financiera on Saturday, starting at 7:00 PM ET.

Dimers' advanced Liga MX model projects Guadalajara as the most likely winner in this Atletico San Luis vs. Guadalajara prediction.

This article offers a closer look at Saturday's match, including best bets and picks.

Atletico San Luis vs. Guadalajara prediction and odds

Using innovative machine learning and statistical analysis, we have simulated the outcome of Saturday's Liga MX game between Atletico San Luis and Guadalajara, forming part of our Liga MX predictions coverage.

Our independent predictive model suggests a 28.1% chance of Atletico San Luis winning, a 47.5% chance for Guadalajara, and a 24.5% chance of a draw.

Additionally, the 2.5-goal over/under has a 53.7% chance of going over, with a 56.2% probability that both teams score.

Latest betting odds

We have sourced the best Liga MX odds in America for this game, which are listed here:

• Moneyline: Guadalajara -125, Atletico San Luis +320
• Total Goals: Over/Under 2.5 (-148/+116)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Moneyline: San Luis @ +320 via DraftKings
• Total Goals: Under 2.5 @ +116 via FanDuel

According to our best Liga MX bets, the top play to make on this game is San Luis to win.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Correct score and BTTS projections

Here are the top three most likely final scores according to our model, with a 1-1 draw being the most probable:

• San Luis 1-1 Guadalajara (11.5% probability)
• San Luis 0-1 Guadalajara (9.6%)
• San Luis 1-2 Guadalajara (9.4%)

When it comes to the both teams to score (BTTS) market, we project a 56.2% chance of both sides finding the net and a 43.8% chance that at least one doesn’t.

These predictions are based on each team's average score according to our machine learning model, which means the most likely correct score can differ from our predicted winner.

Game info & kickoff details

Saturday's Liga MX game between Atletico San Luis and Guadalajara at Estadio Libertad Financiera is scheduled to begin at 7:00 PM ET.

• Who: Atletico San Luis vs. Guadalajara
• Date: Saturday, September 5, 2026
• Time: 7:00 PM ET/4:00PM PT
• Venue: Estadio Libertad Financiera

Conclusion

According to our computer model, Atletico San Luis has a 28.1% win probability on Saturday, Guadalajara has a 47.5% win probability, and there is a 24.5% chance that the game will end in a draw.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.