Flavio Cobolli vs. Brandon Nakashima prediction, odds, picks for ATP Lyon Open 2026

Using powerful machine learning and data analysis, we have re-simulated the result of Friday's Cobolli-Nakashima men's singles match, forming part of our tennis predictions coverage.

Our independent predictive model currently gives Nakashima a 60% chance of beating Cobolli at the ATP Lyon Open tournament. Additionally, Nakashima has a 57% chance of winning the first set. The simulations also show Cobolli (+2.5) has a 53% chance of covering the games spread, while the under 25.5 games has a 60% chance of hitting, according to our model.

Latest betting odds

We have researched the most up-to-date betting odds in America for this match, which are listed here:

• Moneyline: Brandon Nakashima -175, Flavio Cobolli +161
• First Set: Cobolli +120, Nakashima -152

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Moneyline: Cobolli @ +161 via DraftKings
• First Set: Nakashima @ -118 via DraftKings

According to our tennis best bets, the top play to make on this match is Flavio Cobolli to win the first set.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & first serve details

The ATP Lyon Open match between Flavio Cobolli and Brandon Nakashima is scheduled to commence on Friday at 1:00 PM ET.

• Who: Flavio Cobolli vs. Brandon Nakashima
• Date: Friday, October 23, 2026
• Approx. Time: 1:00 PM ET/10:00 AM PT
• Tournament: ATP Lyon, France Men's Singles 2026
• Round: Quarterfinals

All dates and times mentioned in this article are United States Eastern Time unless otherwise stated.

Conclusion

We predict Brandon Nakashima, with a 60% win probability, will likely beat Flavio Cobolli at the ATP Lyon Open tournament.

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This article's predictions and probabilities are generated by Dimers' proprietary Tennis prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.