Flavio Cobolli vs. Stan Wawrinka prediction, odds, picks for ATP Lyon Open 2026

Using trusted machine learning and data, we have re-simulated the outcome of Thursday's Cobolli-Wawrinka men's singles match, forming part of our tennis predictions coverage.

Our leading predictive model currently gives Cobolli a 72% chance of defeating Wawrinka at the ATP Lyon Open tournament. Additionally, Cobolli has a 67% chance of winning the first set. The simulations also show Cobolli (-2.5) has a 53% chance of covering the games spread, while the under 23.5 games has a 60% chance of hitting, according to our model.

Latest betting odds

We have researched the most up-to-date betting odds in America for this match, which are listed here:

• Moneyline: Stan Wawrinka +240, Flavio Cobolli -280
• First Set: Cobolli -227, Wawrinka +175

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Moneyline: Wawrinka @ +240 via DraftKings
• First Set: Wawrinka @ -135 via DraftKings

According to our tennis best bets, the top play to make on this match is over 23.5 total games.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & first serve details

The ATP Lyon Open match between Flavio Cobolli and Stan Wawrinka is scheduled to begin on Thursday at 1:00 PM ET.

• Who: Flavio Cobolli vs. Stan Wawrinka
• Date: Thursday, October 22, 2026
• Approx. Time: 1:00 PM ET/10:00 AM PT
• Tournament: ATP Lyon, France Men's Singles 2026
• Round: Round of 16

All dates and times mentioned in this article are United States Eastern Time unless otherwise noted.

Conclusion

We predict Flavio Cobolli, with a 72% win probability, will likely beat Stan Wawrinka at the ATP Lyon Open tournament.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary Tennis prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.