Buffalo vs. Pittsburgh prediction, odds, pick for Nov. 5, 2026

Pittsburgh is favored to beat Buffalo at Petersen Events Center on Thursday (7:00 PM ET), according to Dimers' men's college basketball model.

Our Buffalo vs. Pittsburgh prediction gives Pittsburgh a 94.8% chance of winning, while the latest odds suggest there's betting value on the under 150.5 points.

Buffalo vs. Pittsburgh key predictions

• Predicted score: Pittsburgh 84-65 Buffalo
• Pittsburgh win probability: 94.8%
• Buffalo win probability: 5.2%
• Pittsburgh -18.5 spread: 50.4% cover probability
• Under 150.5 points: 52.9% probability

Our men's college basketball predictions project each team's final score using offensive and defensive efficiency, recent performance, long-term trends, and matchup-specific factors.

We calculate win, spread, and total probabilities based on these projections and historical CBB scoring patterns, then compare them with the latest odds to find betting value.

Buffalo vs. Pittsburgh odds

Here are the best available odds across the moneyline, spread, and total points markets we track.

• Buffalo moneyline: +1500 (DraftKings)
• Pittsburgh moneyline: -3000 (BetMGM)
• Buffalo +18.5: -105 (BetMGM)
• Pittsburgh -18.5: -110 (FanDuel)
• Over 150.5 points: -115 (BetMGM)
• Under 150.5 points: -105 (BetMGM)

Odds are subject to change and may vary by location.

Buffalo vs. Pittsburgh pick: Under 150.5 (-105)

Our model makes Pittsburgh the likelier winner, but our best value bet is the under 150.5 total points at -105 on BetMGM.

Those odds give the under an implied probability of 51.2%, while our model puts it at 52.9%.

That's a 1.7% edge, the largest across the moneyline, spread, and total points markets for this game.

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Buffalo vs. Pittsburgh game details

• Matchup: Buffalo Bulls vs. Pittsburgh Panthers
• Date: Thursday, November 5, 2026
• Time: 7:00 PM ET
• Venue: Petersen Events Center

About this prediction

This preview uses predictions from our men's college basketball models, presented through a template written by our editorial team. Matchup details fill in automatically.

Predictions are estimates, not guarantees, and can change as new information comes in, such as injury news or lineup changes. Learn how our predictions work.

Dimers encourages responsible gambling.