Holy Cross vs. Villanova prediction, odds, pick for Nov. 6, 2026

Villanova is favored to beat Holy Cross at The William B. Finneran Pavilion on Friday (7:00 PM ET), according to Dimers' men's college basketball model.

Our Holy Cross vs. Villanova prediction gives the Crusaders a 98.5% chance of winning, but the latest odds suggest there's betting value on Holy Cross to cover at +31.5.

Holy Cross vs. Villanova key predictions

• Predicted score: Villanova 88-61 Holy Cross
• Villanova win probability: 98.5%
• Holy Cross win probability: 1.5%
• Holy Cross +31.5 spread: 56.0% cover probability
• Under 151.5 points: 51.8% probability

Our men's college basketball predictions project each team's final score using offensive and defensive efficiency, recent performance, long-term trends, and matchup-specific factors.

We calculate win, spread, and total probabilities based on these projections and historical CBB scoring patterns, then compare them with the latest odds to find betting value.

Holy Cross vs. Villanova odds

Here are the best available odds across the moneyline, spread, and total points markets we track.

• Holy Cross moneyline: +8000 (FanDuel)
• Villanova moneyline: -10000 (BetMGM)
• Holy Cross +31.5: -105 (BetMGM)
• Villanova -31.5: -105 (FanDuel)
• Over 151.5 points: -110 (Caesars Sportsbook)
• Under 151.5 points: -105 (DraftKings)

Odds are subject to change and may vary by location.

Holy Cross vs. Villanova pick: Holy Cross +31.5 (-105)

Our model makes Villanova the likelier winner, but our best value bet is Villanova to cover the +31.5 spread at -105 on BetMGM.

Those odds give Holy Cross an implied cover probability of 51.2%, while our model puts it at 56.0%.

That's a 4.8% edge, the largest across the moneyline, spread, and total points markets for this game.

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Holy Cross vs. Villanova game details

• Matchup: Holy Cross Crusaders vs. Villanova
• Date: Friday, November 6, 2026
• Time: 7:00 PM ET
• Venue: The William B. Finneran Pavilion

About this prediction

This preview uses predictions from our men's college basketball models, presented through a template written by our editorial team. Matchup details fill in automatically.

Predictions are estimates, not guarantees, and can change as new information comes in, such as injury news or lineup changes. Learn how our predictions work.

Dimers encourages responsible gambling.