Sep 25, 2026
Clemson vs. California prediction: Why Clemson is favored to win in college football Week 4 [2026]
Read Article College football picks today: Week 4 Friday best bets include Harvard vs. Brown play [9/25/2026]
Updated: | First published:
Written by Ryan Leaver, Senior Sports and Betting Editor
Get college football picks and best bets for Friday, September 25, 2026.
Today’s college football picks for September 25, 2026 are here, with Harvard vs. Brown among the top plays identified by our model across Friday’s college football play.
Dimers’ predictive analytics engine runs 24/7, going over the latest football odds to uncover legitimate betting edges. The result? Data-backed picks that help Dimers Pro members make smarter decisions.
List of college football picks tonight [9/25, updated 5:42PM ET]
Below, you’ll find today’s college football best bets, ranked by edge for Friday, September 25, 2026.
Brown +13.5 (-110)
- Edge: 2.8%
- Probability: 55.1%
- Matchup: Harvard vs. Brown (7:00PM ET)
Our model has identified value on Brown +13.5 at -110 odds. A 55.1% probability produces an edge of 2.8%, making this the strongest play for today's college football slate.
Harvard vs. Brown Over 42.5 points (-111)
- Edge: 2.8%
- Probability: 55.4%
- Matchup: Harvard vs. Brown (7:00PM ET)
Harvard vs. Brown over 42.5 points carries a 2.8% edge and a probability of 55.4% at -111 odds, according to our model.
NCAAF best bets summary: Friday, 9/25/2026
As of 5:42PM ET, here are our top college football bets by edge recommended by our model:
| Matchup | Bet | Odds | Edge | Prob. |
|---|---|---|---|---|
| Harvard vs. Brown | Brown +13.5 | -110 @ Caesars | 2.8% | 55.1% |
| Harvard vs. Brown | Over 42.5 points | -111 @ DraftKings | 2.8% | 55.4% |
List of upcoming college football games to bet on now
- Navy vs. UAB (7:00PM ET, Friday)
- Howard vs. Rutgers (7:00PM ET, Friday)
- Harvard vs. Brown (7:00PM ET, Friday)
- Northwestern vs. Indiana (8:00PM ET, Friday)
- Clemson vs. California (10:30PM ET, Friday)
- Texas vs. Tennessee (12:00PM ET, Saturday)
- Illinois vs. Ohio State (12:00PM ET, Saturday)
- Wake Forest vs. Louisville (12:00PM ET, Saturday)
- Ball State vs. Kent State (12:00PM ET, Saturday)
- Colorado State vs. UTSA (12:00PM ET, Saturday)
College football offer for Week 4
Make the most of the picks in this article—including Brown +13.5—with the Underdog Fantasy offer below:
Conclusion
Our college football best bets are locked and loaded for September 25, 2026, featuring plays such as Brown +13.5 vs. Harvard and over 42.5 points also in the Harvard vs. Brown matchup. Powered by advanced simulations, these picks are here to boost your betting game.
Our predictions are drawn from current data to help you make informed decisions. For additional resources and advice, head to our Responsible Gambling hub.
All odds and probabilities in this article are correct and accurate at the time of publication.
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Ryan Leaver uses advanced statistical models and simulations to predict outcomes and provide predictions for the NBA, NFL, college football, college basketball, and soccer. He offers detailed game previews, best bets, props, and futures articles.
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