Northwestern vs. Indiana prediction: Why Indiana is favored to win in college football Week 4 [2026]

Using innovative machine learning and data, we have re-simulated the result of Northwestern vs. Indiana, forming part of our college football predictions coverage.

Our independent predictive model gives Indiana a 95.8% chance of defeating Northwestern. Our predicted final score has Indiana winning 36-14. According to our model, Indiana (-20.5) has a 51.7% chance of covering the spread, while the 50.5-point over/under has a 51.5% chance of going over.

Latest betting odds

We have sourced the best college football odds in America for this game, which are listed here:

• Spread: Northwestern +20.5 (-105) / Indiana -20.5 (-104)
• Moneyline: Northwestern +1000, Indiana -1700
• Total: Over/Under 50.5 (-106/-110)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Indiana -20.5 @ -104 via FanDuel
• Moneyline: Indiana @ -1700 via FanDuel
• Total: Over 50.5 @ -106 via Caesars

According to our college football best bets, the top play to make on this game is Indiana -20.5 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Friday's college football matchup between Indiana and Northwestern at Memorial Stadium is scheduled to start at 8:00 PM ET.

• Who: Northwestern vs. Indiana
• Date: Friday, September 25, 2026
• Time: 8:00 PM ET/5:00PM PT
• Venue: Memorial Stadium

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Conclusion

We predict Indiana, with a 95.8% win probability, will likely beat Northwestern in Friday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.