Colorado vs. Northwestern prediction favors Northwestern to win in college football Week 3 [2026]

Using trusted machine learning and data, we have re-simulated the outcome of Colorado vs. Northwestern, forming part of our college football predictions coverage.

Our famous predictive model currently gives Northwestern a 63.1% chance of defeating Colorado. Our predicted final score has Northwestern winning 26-22. According to our model, Northwestern (-3.5) has a 50.8% chance of covering the spread, while the over/under total of 47.5 points has a 54.4% chance of going over.

Latest betting odds

We have sourced the best college football odds in America for this game, which are listed here:

• Spread: Colorado +3.5 (-108) / Northwestern -3.5 (-104)
• Moneyline: Colorado +150, Northwestern -170
• Total: Over/Under 47.5 (-112/-104)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Northwestern -3.5 @ -104 via FanDuel
• Moneyline: Northwestern @ -170 via bet365
• Total: Over 47.5 @ -112 via DraftKings

According to our college football best bets, the top play to make on this game is Over 47.5 total points.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football game between Northwestern and Colorado at Ryan Field is scheduled to commence at 7:30 PM ET.

• Who: Colorado vs. Northwestern
• Date: Saturday, September 19, 2026
• Time: 7:30 PM ET/4:30PM PT
• Venue: Ryan Field

College football Week 3 promos

Make the most of Dimers' Colorado vs. Northwestern predictions by exploring the Bet365 Sportsbook offer below:

Plus, check out the latest details on the current offer from Kalshi.

Conclusion

We predict Northwestern, with a 63.1% win probability, will likely beat Colorado in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.