FSU vs. Louisville prediction favors Louisville to win in college football Week 6 [2026]

Using trusted machine learning and data analysis, we have re-simulated the outcome of FSU vs. Louisville, forming part of our college football predictions coverage.

Our independent predictive model gives Louisville a 62.5% chance of defeating Florida State. Our predicted final score has Louisville winning 31-27. According to our model, Louisville (-3.5) has a 50.4% chance of covering the spread, while the 59.5-point over/under has a 50.8% chance of staying under.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: FSU +3.5 (-105) / Louisville -3.5 (-109)
• Moneyline: FSU +154, Louisville -180
• Total: Over/Under 59.5 (-109/-106)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Florida State +3.5 @ -105 via FanDuel
• Moneyline: Louisville @ -180 via BetRivers
• Total: Under 59.5 @ -106 via FanDuel

According to our best college football bets, the top play to make on this game is Under 59.5 total points.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Friday's college football matchup between Louisville and FSU at L&N Federal Credit Union Stadium is scheduled to start at 7:00 PM ET.

• Who: Florida State vs. Louisville
• Date: Friday, October 9, 2026
• Time: 7:00 PM ET/4:00PM PT
• Venue: L&N Federal Credit Union Stadium

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Conclusion

We predict Louisville, with a 62.5% win probability, will likely beat Florida State in Friday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.