James Madison vs. Old Dominion prediction favors James Madison to win in college football Week 4 [2026]

Using powerful machine learning and data analysis, we have re-simulated the result of James Madison vs. Old Dominion, forming part of our college football predictions coverage.

Our famous predictive model currently gives James Madison a 67.1% chance of defeating Old Dominion. Our predicted final score has James Madison winning 25-20. According to our model, Old Dominion (+6.5) has a 53.1% chance of covering the spread, while the 43.5-point over/under has a 56.0% chance of going over.

Latest betting odds

We have sourced the best college football odds in America for this game, which are listed here:

• Spread: James Madison -6.5 (-115) / Old Dominion +6.5 (+100)
• Moneyline: James Madison -245, Old Dominion +215
• Total: Over/Under 43.5 (-113/-104)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Old Dominion +6.5 @ +100 via bet365
• Moneyline: Old Dominion @ +215 via FanDuel
• Total: Over 43.5 @ -113 via BetRivers

According to our college football best bets, the top play to make on this game is Old Dominion +6.5 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football game between Old Dominion and James Madison at Kornblau Field at S.B. Ballard Stadium is scheduled to begin at 6:00 PM ET.

• Who: James Madison vs. Old Dominion
• Date: Saturday, September 26, 2026
• Time: 6:00 PM ET/3:00PM PT
• Venue: Kornblau Field at S.B. Ballard Stadium

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Conclusion

We predict James Madison, with a 67.1% win probability, will likely beat Old Dominion in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.