West Florida vs. Southeast Missouri State prediction favors Southeast Missouri State to win in college football Week 4 [2026]

Using trusted machine learning and data, we have re-simulated the result of West Florida vs. Southeast Missouri State, forming part of our college football predictions coverage.

Our famous predictive model currently gives Southeast Missouri State a 64.1% chance of beating West Florida. Our predicted final score has Southeast Missouri State winning 28-23. According to our model, West Florida (+5.5) has a 50.8% chance of covering the spread, while the 51.5-point over/under has a 51.8% chance of going over.

Latest betting odds

We have sourced the best college football odds in America for this game, which are listed here:

• Spread: West Florida +5.5 (-115) / Southeast Missouri State -5.5 (-115)
• Moneyline: West Florida +158, Southeast Missouri State -171
• Total: Over/Under 51.5 (-115/-106)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: West Florida +5.5 @ -115 via bet365
• Moneyline: Southeast Missouri State @ -171 via DraftKings
• Total: Over 51.5 @ -115 via bet365

According to our college football best bets, the top play to make on this game is Southeast Missouri State to win.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football matchup between Southeast Missouri State and West Florida at Houck Field is scheduled to begin at 7:00 PM ET.

• Who: West Florida vs. Southeast Missouri State
• Date: Saturday, September 26, 2026
• Time: 7:00 PM ET/4:00PM PT
• Venue: Houck Field

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Conclusion

We predict Southeast Missouri State, with a 64.1% win probability, will likely beat West Florida in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.