Nebraska vs. Michigan State prediction: Why Nebraska is favored to win in college football Week 4 [2026]

Using trusted machine learning and data, we have re-simulated the outcome of Nebraska vs. Michigan State, forming part of our college football predictions coverage.

Our leading predictive model gives Nebraska a 69.7% chance of beating Michigan State. Our predicted final score has Nebraska winning 27-21. According to our model, Nebraska (-5.5) has a 52.3% chance of covering the spread, while the over/under total of 48.5 points has a 52.2% chance of going over.

Latest betting odds

We have sourced the best college football odds in America for this game, which are listed here:

• Spread: Nebraska -5.5 (-110) / Michigan State +5.5 (-102)
• Moneyline: Nebraska -225, Michigan State +188
• Total: Over/Under 48.5 (-110/-103)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Nebraska -5.5 @ -110 via Caesars
• Moneyline: Nebraska @ -225 via bet365
• Total: Over 48.5 @ -110 via BetRivers

According to our college football best bets, the top play to make on this game is Nebraska -5.5 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football game between Michigan State and Nebraska at Spartan Stadium is scheduled to commence at 5:00 PM ET.

• Who: Nebraska vs. Michigan State
• Date: Saturday, September 26, 2026
• Time: 5:00 PM ET/2:00PM PT
• Venue: Spartan Stadium

College football Week 4 promos

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Conclusion

We predict Nebraska, with a 69.7% win probability, will likely beat Michigan State in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.