Southern University vs. Jackson State prediction favors Jackson State to win in college football Week 4 [2026]

Using powerful machine learning and data, we have re-simulated the outcome of Southern University vs. Jackson State, forming part of our college football predictions coverage.

Our independent predictive model currently gives Jackson State a 94.6% chance of beating Southern University. Our predicted final score has Jackson State winning 38-16. According to our model, Jackson State (-20.5) has a 55.3% chance of covering the spread, while the over/under total of 55.5 points has an equal 50-50 chance of hitting.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: Southern University +20.5 (-112) / Jackson State -20.5 (-110)
• Moneyline: Southern University +750, Jackson State -1340
• Total: Over/Under 55.5 (-115/-106)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Jackson State -20.5 @ -110 via Caesars
• Moneyline: Jackson State @ -1340 via DraftKings
• Total: Under 55.5 @ -106 via Caesars

According to our college football best bets, the top play to make on this game is Jackson State -20.5 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Saturday's college football game between Jackson State and Southern University at Mississippi Veterans Memorial Stadium is scheduled to commence at 7:00 PM ET.

• Who: Southern University vs. Jackson State
• Date: Saturday, September 26, 2026
• Time: 7:00 PM ET/4:00PM PT
• Venue: Mississippi Veterans Memorial Stadium

College football Week 4 promos

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Conclusion

We predict Jackson State, with a 94.6% win probability, will likely beat Southern University in Saturday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary College Football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.