Virginia Tech vs. SMU prediction favors Southern Methodist to win in college football Week 10 [2026]

Using trusted machine learning and data analysis, we have re-simulated the outcome of Virginia Tech vs. SMU, forming part of our college football predictions coverage.

Our leading predictive model gives Southern Methodist a 67.4% chance of defeating Virginia Tech. Our predicted final score has Southern Methodist winning 31-25. According to our model, Virginia Tech (+7.5) has a 56.5% chance of covering the spread, while the 57.5-point over/under has a 52.0% chance of staying under.

Latest betting odds

We have researched the best college football odds in America for this game, which are listed here:

• Spread: Virginia Tech +7.5 (-144) / SMU -7.5 (+141)
• Moneyline: Virginia Tech +194, SMU -199
• Total: Over/Under 57.5 (+106/-108)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Southern Methodist -7.5 @ 41¢ via Novig
• Moneyline: Southern Methodist @ 66¢ via Novig
• Total: Under 57.5 @ 52¢ via Novig

According to our best college football bets, the top play to make on this game is Southern Methodist -7.5 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Friday's college football game between SMU and Virginia Tech at Gerald J. Ford Stadium is scheduled to commence at 7:00 PM ET.

• Who: Virginia Tech vs. Southern Methodist
• Date: Friday, November 6, 2026
• Time: 7:00 PM ET/4:00 PM PT
• Venue: Gerald J. Ford Stadium

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Conclusion

We predict Southern Methodist, with a 67.4% win probability, will likely beat Virginia Tech in Friday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary college football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.