James Madison vs. Southern Miss prediction favors James Madison to win in college football Week 10 [2026]

Using powerful machine learning and data analysis, we have re-simulated the result of James Madison vs. Southern Miss, forming part of our college football predictions coverage.

Our leading predictive model gives James Madison an 82.2% chance of defeating Southern Miss. Our predicted final score has James Madison winning 35-22. According to our model, Southern Miss (+13.5) has a 53.5% chance of covering the spread, while the over/under total of 56.5 points has a 53.9% chance of going over.

Latest betting odds

We have sourced the best college football odds in America for this game, which are listed here:

• Spread: James Madison -13.5 (-108) / Southern Miss +13.5 (-105)
• Moneyline: James Madison -488, Southern Miss +475
• Total: Over/Under 56.5 (-120/+115)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Southern Miss +13.5 @ -105 via FanDuel
• Moneyline: Southern Miss @ +475 via BetRivers
• Total: Under 56.5 @ 46¢ via Novig

According to our college football best bets, the top play to make on this game is Southern Miss +13.5 at the spread.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & kickoff details

Thursday's college football matchup between Southern Miss and James Madison at M.M. Roberts Stadium is scheduled to begin at 8:00 PM ET.

• Who: James Madison vs. Southern Miss
• Date: Thursday, November 5, 2026
• Time: 8:00 PM ET/5:00 PM PT
• Venue: M.M. Roberts Stadium

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Conclusion

We predict James Madison, with an 82.2% win probability, will likely beat Southern Miss in Thursday's college football matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary college football prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.