Santos Laguna vs. Guadalajara prediction, odds, Liga MX picks [8/16/2026]

Liga MX action continues on Sunday at 9:10 PM ET as Guadalajara takes on Santos Laguna at Estadio Corona.

Dimers' advanced Liga MX model projects Guadalajara as the most likely winner in this Santos Laguna vs. Guadalajara prediction.

This article offers an expanded analysis of Sunday's match, including best bets and picks.

Santos Laguna vs. Guadalajara prediction: Who will win?

Using trusted machine learning and data, we have simulated the result of Sunday's Liga MX matchup between Santos Laguna and Guadalajara, forming part of our Liga MX predictions coverage.

Our independent predictive model currently suggests an 18.8% chance of Santos Laguna winning, a 58.7% chance for Guadalajara, and a 22.5% chance of a draw.

Additionally, the 2.5-goal over/under has a 52.7% chance of going over, with a 51.3% probability that both teams score.

Santos Laguna vs. Guadalajara odds

We have researched the best Liga MX odds in America for this game, which are listed here:

• Moneyline: Guadalajara -180, Santos Laguna +460

All odds are correct at the time of publication and are subject to change.

Santos Laguna vs. Guadalajara picks and best bet

After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Moneyline: Santos Laguna @ +460 via BetRivers
• Total Goals: Under 2.5 @ +135 via Bet365

According to our Liga MX best bets, the top play to make on this game is Under 2.5 total goals.

These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.

Santos Laguna vs. Guadalajara: Correct score and BTTS predictions

Here are the top three most likely final scores according to our model, with a 1-0 Guadalajara win being the most probable:

• Santos Laguna 0-1 Guadalajara (11.4% probability)
• Santos Laguna 1-1 Guadalajara (10.7%)
• Santos Laguna 0-2 Guadalajara (10.5%)

When it comes to the both teams to score (BTTS) market, we project a 51.3% chance of both sides finding the net and a 48.7% chance that at least one doesn’t.

Santos Laguna vs. Guadalajara game-day updates and essential details

Sunday's game between Santos Laguna and Guadalajara at Estadio Corona is scheduled to commence at 9:10 PM ET.

• Who: Santos Laguna vs. Guadalajara
• Date: Sunday, August 16, 2026
• Time: 9:10 PM ET/6:10PM PT
• Venue: Estadio Corona

Conclusion

According to our computer model, Santos Laguna has an 18.8% win probability on Sunday, Guadalajara has a 58.7% win probability, and there is a 22.5% chance that the game will end in a draw.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.