White Sox vs. Red Sox prediction: Boston favored to win Wednesday's MLB matchup [8/5/2026]
Get Chicago White Sox vs Boston Red Sox predictions for MLB Wednesday.

MLB action continues on Wednesday at 7:10 PM ET as the Chicago White Sox take on the Boston Red Sox at Fenway Park.
Sonny Gray (13-2, 2.93 ERA) will be the starting pitcher for the Red Sox, while the White Sox are going with Sean Burke (7-5, 3.04 ERA).
Dimers' advanced MLB model projects the Red Sox as the most likely winner in this White Sox vs. Red Sox prediction.
This article offers further insights into Wednesday's matchup, including best bets and picks.
White Sox vs. Red Sox prediction: Who will win and cover?
Our independent predictive model currently gives the Red Sox a 58.8% chance of beating the White Sox.
According to our model, the White Sox (+1.5) have a 58.8% chance of covering the run line, while the 8.5-run over/under has a 54.8% chance of going over,.
White Sox vs. Red Sox odds [8/5/2026]
We have researched the best MLB odds in America for this game, which are listed here:
| Bet Type | White Sox | Red Sox |
|---|---|---|
| Run Line | +1.5 (-167) | -1.5 (+163) |
| Moneyline | +125 | -126 |
| Total | o8.5 (+106) | u8.5 (-108) |
All odds are correct at the time of publication and are subject to change.
White Sox vs. Red Sox picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Red Sox -1.5 | +163 |
| Moneyline | Red Sox | -126 |
| Total | Over 8.5 | +106 |
According to our MLB best bets, the top play to make on this game is Over 8.5 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
White Sox vs. Red Sox game-day updates and essential details
Wednesday's MLB action between the Red Sox and White Sox at Fenway Park is scheduled to start at 7:10 PM ET.
- Who: Chicago White Sox vs. Boston Red Sox
- Date: Wednesday, August 5, 2026
- Time: 7:10 PM ET/4:10PM PT
- Venue: Fenway Park
Conclusion
We predict the Red Sox, with a 58.8% win probability, will likely beat the White Sox in Wednesday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
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