Sep 26, 2026
Cardinals vs. Brewers prediction: Why Milwaukee is favored to win Saturday's MLB matchup [9/26/2026]
Read Article Astros vs. Athletics prediction: Why Houston is favored to win Saturday's MLB matchup [9/26/2026]
Updated: | First published:
Written by Ryan Leaver, Senior Sports and Betting Editor
Dimers' simulation model projects a 56.4% win probability for the Astros at Sutter Health Park.
will square off with the Houston Astros in MLB action at Sutter Health Park on Saturday, starting at 9:40 PM ET.
Jack Perkins (3-12, 5.90 ERA) will start on the mound for the Athletics, up against Hayden Wesneski (5-2, 3.50 ERA) for the Astros.
Dimers' proven MLB model projects the Astros as the most likely winner in this Astros vs. Athletics prediction.
This article offers further insights into Saturday's matchup, including best bets and picks.
Astros vs. A's prediction and odds
Using powerful machine learning and data, we have re-simulated the result of Saturday's MLB game between the Astros and Athletics, forming part of our MLB predictions coverage.
Our independent predictive model gives the Astros a 56.4% chance of beating the Athletics. According to our model, the Athletics (+1.5) have a 54.3% chance of covering the run line, while the over/under total of 9.5 runs has a 52.8% chance of going over.
Latest betting odds
We have researched the best MLB odds in America for this game, which are listed here:
- Run Line: Astros -1.5 (+104) / Athletics +1.5 (-108)
- Moneyline: Astros -150, Athletics +150
- Total: Over/Under 9.5 (-108/+108)
All odds are correct at the time of publication and are subject to change.
Model picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:
- Run line: Athletics +1.5 @ 52¢ via Novig
- Moneyline: Athletics @ 40¢ via Polymarket
- Total: Over 9.5 @ 52¢ via Polymarket
According to our MLB best bets, the top play to make on this game is Athletics to win.
These picks are based on our probabilities matched against the implied probabilities from the current available odds.
Game info & first pitch details
Saturday's MLB matchup between the Athletics and Astros at Sutter Health Park is scheduled to begin at 9:40 PM ET.
- Who: Houston Astros vs. Athletics
- Date: Saturday, September 26, 2026
- Time: 9:40 PM ET/6:40PM PT
- Venue: Sutter Health Park
Conclusion
We predict the Astros, with a 56.4% win probability, will likely beat the Athletics in Saturday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
This article's predictions and probabilities are generated by Dimers' proprietary MLB prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.
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Ryan Leaver uses advanced statistical models and simulations to predict outcomes and provide predictions for the NBA, NFL, college football, college basketball, and soccer. He offers detailed game previews, best bets, props, and futures articles.
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