Dodgers vs. Reds prediction: Why Dodgers are favored to win Wednesday's MLB matchup [9/16/2026]

The Cincinnati Reds will face the favored Los Angeles Dodgers in MLB action at Great American Ball Park on Wednesday, starting at 6:40 PM ET.

Andrew Abbott (6-11, 4.78 ERA) will be on the bump for the Reds, while the Dodgers have opted for Blake Snell (4-1, 1.91 ERA).

Dimers' advanced MLB model projects the Dodgers as the most likely winner in this Dodgers vs. Reds prediction.

This article offers a closer look at Wednesday's matchup, including best bets and picks.

Dodgers vs. Reds prediction and odds

Using powerful machine learning and data, we have re-simulated the result of Wednesday's MLB game between the Dodgers and Reds, forming part of our MLB predictions coverage.

Our famous predictive model currently gives the Dodgers a 64.8% chance of defeating the Reds. According to our model, the Dodgers (-1.5) have a 53.7% chance of covering the run line, while the 8.5-run over/under has a 57.3% chance of going over.

Latest betting odds

We have sourced the best MLB odds in America for this game, which are listed here:

• Run Line: Dodgers -1.5 (-125) / Reds +1.5 (+122)
• Moneyline: Dodgers -208, Reds +203
• Total: Over/Under 8.5 (+113/-111)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Run line: Reds +1.5 @ 45¢ via Novig
• Moneyline: Reds @ 33¢ via Novig
• Total: Over 8.5 @ 47¢ via Polymarket

According to our MLB best bets, the top play to make on this game is Over 8.5 total runs.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & first pitch details

Wednesday's MLB matchup between the Reds and Dodgers at Great American Ball Park is scheduled to start at 6:40 PM ET.

• Who: Los Angeles Dodgers vs. Cincinnati Reds
• Date: Wednesday, September 16, 2026
• Time: 6:40 PM ET/3:40PM PT
• Venue: Great American Ball Park

Conclusion

We predict the Dodgers, with a 64.8% win probability, will likely beat the Reds in Wednesday's MLB matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary MLB prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.