St Louis City vs. San Diego FC prediction, odds, MLS Cup first round picks [10/31/2026]

St Louis City and San Diego FC will lock horns in the MLS Cup first round at CITYPARK on Saturday, starting at 3:00 PM ET.

Dimers' advanced MLS model projects St Louis City as the most likely winner in this St Louis City vs. San Diego FC prediction.

This article offers an expanded analysis of Saturday's match, including best bets and picks.

St Louis City vs. San Diego FC prediction and odds

Using powerful machine learning and data, we have re-simulated the outcome of Saturday's MLS matchup between St Louis City and San Diego FC, forming part of our MLS predictions coverage.

Our famous predictive model indicates a 59.2% chance of St Louis City winning, a 21.4% chance for San Diego FC, and a 19.4% chance of a draw. Additionally, the over/under total of 2.5 goals has a 71.5% chance of going over., according to our model.

Latest betting odds

We have researched the best MLS odds in America for this game, which are listed here:

• Moneyline: San Diego FC +270, St Louis City -110
• Total Goals: Over/Under 2.5 (-233/+223)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet for MLS Cup first round

After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Moneyline: St Louis City @ -110 via Fanatics
• Total Goals: Over 2.5 @ -233 via Novig

According to our MLS best bets, the top play to make on this game is St Louis City to win.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Correct score projections

Here are the top three most likely final scores according to our model, with a 2-1 St Louis City win being the most probable:

• St Louis City 2-1 San Diego FC (9.2% probability)
• St Louis City 1-1 San Diego FC (7.9%)
• St Louis City 3-1 San Diego FC (7.2%)

Game info & kickoff details

Saturday's MLS game between St Louis City and San Diego FC in MLS at CITYPARK is scheduled to start at 3:00 PM ET.

• Who: St Louis City vs. San Diego FC
• Date: Saturday, October 31, 2026
• Time: 3:00 PM ET/12:00 PM PT
• Venue: CITYPARK

Conclusion

According to our computer model, St Louis City has a 59.2% win probability on Saturday, San Diego FC has a 21.4% win probability, and there is a 19.4% chance that the game will end in a draw.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary MLS prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.