Alexander Zverev vs. Botic Van de Zandschulp prediction, odds, picks for US Open 2026

Using powerful machine learning and data, we have re-simulated the result of Wednesday's Zverev-Van de Zandschulp men's singles match, forming part of our tennis predictions coverage.

Our leading predictive model gives Zverev an 89% chance of beating Van de Zandschulp in the US Open 2026.

Additionally, Zverev has an 82% chance of winning the first set. The simulations also show Zverev (-6.5) has a 53% chance of covering the games spread, while the under 35.5 games has a 65% chance of hitting, according to our model.

Latest betting odds

We have researched the most up-to-date betting odds in America for this match, which are listed here:

• Moneyline: Botic Van de Zandschulp +590, Alexander Zverev -833
• First Set: Zverev -400, Van de Zandschulp +300

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Moneyline: Zverev @ -833 via DraftKings
• First Set: Van de Zandschulp @ -140 via DraftKings

According to our best tennis bets, the top play to make on this match is over 35.5 total games.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Game info & first serve details

The US Open 2026 match between Alexander Zverev and Botic Van de Zandschulp is scheduled to start on Wednesday at 7:45 PM ET.

• Who: Alexander Zverev vs. Botic Van de Zandschulp
• Date: Wednesday, September 9, 2026
• Approx. Time: 7:45 PM ET/4:45PM PT
• Tournament: US Open Men's Singles 2026
• Round: Quarterfinals

All dates and times in this article are United States Eastern Time unless otherwise stated.

Conclusion

We predict Alexander Zverev, with an 89% win probability, will likely beat Botic Van de Zandschulp at the US Open 2026.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.