College football picks today: Week 10 Friday best bets include South Florida vs. East Carolina play [11/6/2026]

South Florida vs. East Carolina Over 45.5 points (+223)

• Edge: 7.0%
• Probability: 38%
• Matchup: South Florida vs. East Carolina (7:30PM ET)

Our model has identified value on Over 45.5 points in South Florida vs. East Carolina at 31¢ odds. A 38% probability produces an edge of 7.0%, making this the strongest play for today's college football slate.

New Mexico vs. Nevada Over 43.5 points (+163)

• Edge: 5.4%
• Probability: 43.4%
• Matchup: New Mexico vs. Nevada (9:00PM ET)

New Mexico vs. Nevada over 43.5 points carries a 5.4% edge and a probability of 43.4% at 38¢ odds, according to our model.

East Carolina +1.5 (55¢)

• Edge: 4.3%
• Probability: 58.8%
• Matchup: South Florida vs. East Carolina (7:30PM ET)

East Carolina +1.5 vs. South Florida at 55¢ odds shows a 4.3% edge, supported by a 58.8% probability in simulations.

TCU vs. Arizona over 44.5 points (-133)

• Edge: 2.5%
• Probability: 59.5%
• Matchup: TCU vs. Arizona (10:15PM ET)

A 2.5% edge and 59.5% probability make TCU vs. Arizona over 44.5 points a value play in the TCU vs. Arizona matchup, per our model.

Southern Methodist -7.5 (+141)

• Edge: 2.0%
• Probability: 43.5%
• Matchup: Virginia Tech vs. Southern Methodist (7:00PM ET)

Southern Methodist -7.5 at 41¢ presents a 2.0% edge, with simulations resulting in a probability of 43.5%.

NCAAF best bets summary: Friday, 11/6/2026

As of 6:02PM ET, here are our top college football bets by edge recommended by our model:

List of upcoming college football games to bet on now

• Virginia Tech vs. Southern Methodist (7:00PM ET, Friday)
• South Florida vs. East Carolina (7:30PM ET, Friday)
• Nebraska vs. Illinois (8:00PM ET, Friday)
• New Mexico vs. Nevada (9:00PM ET, Friday)
• TCU vs. Arizona (10:15PM ET, Friday)
• Brigham Young vs. Utah (12:00PM ET, Saturday)
• Texas vs. Missouri (12:00PM ET, Saturday)
• UCLA vs. Minnesota (12:00PM ET, Saturday)
• Clemson vs. Syracuse (12:00PM ET, Saturday)
• Iowa State vs. Baylor (12:00PM ET, Saturday)

College football offer for Week 10

Make the most of the picks in this article, including Over 45.5 points, with the Bet365 Sportsbook offer below:

Conclusion

Our college football best bets are locked and loaded for November 6, 2026, featuring plays such as over 45.5 points in the South Florida vs. East Carolina matchup and over 43.5 points in the New Mexico vs. Nevada matchup. Powered by advanced simulations, these picks are here to boost your betting game.

Our predictions are sourced from current data to help you make informed decisions. For additional resources and advice, head to our Responsible Gambling hub.

All odds and probabilities in this article are correct and accurate at the time of publication.